So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cook, Brandoch; Rafiq, Ruhina; Lee, Heejin; Banks, Kelly M.; El-Debs, Mohammed; Chiaravalli, Jeanne; Glickman, J. Fraser; Das, Bhaskar C.; Chen, Shuibing; Evans, Todd researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Category: tetrahydrofurans.They published the article 《Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β》 about this compound( cas:20028-53-9 ) in Cell Chemical Biology. Keywords: MAPK human osteoblast differentiation; differentiation; osteogenesis; signaling; zebrafish. We’ll tell you more about this compound (cas:20028-53-9).
Disorders of bone healing and remodeling are indications with an unmet need for effective pharmacol. modulators. We used a high-throughput screen to identify activators of the bone marker alk. phosphatase (ALP), and discovered 6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one (DIPQUO). DIPQUO markedly promotes osteoblast differentiation, including expression of Runx2, Osterix, and Osteocalcin. Treatment of human mesenchymal stem cells with DIPQUO results in osteogenic differentiation including a significant increase in calcium matrix deposition. DIPQUO stimulates ossification of emerging vertebral primordia in developing zebrafish larvae, and increases caudal fin osteogenic differentiation during adult zebrafish fin regeneration. The stimulatory effect of DIPQUO on osteoblast differentiation and maturation was shown to be dependent on the p38 MAPK pathway. Inhibition of p38 MAPK signaling or specific knockdown of the p38-β isoform attenuates DIPQUO induction of ALP, suggesting that DIPQUO mediates osteogenesis through activation of p38-β, and is a promising lead candidate for development of bone therapeutics.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem