The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-5-chlorobenzaldehyde(SMILESS: NC1=CC=C(Cl)C=C1C=O,cas:20028-53-9) is researched.Electric Literature of C7H6ClNO. The article 《Highly Regioselective Friedlaender Annulations with Unmodified Ketones Employing Novel Amine Catalysts: Syntheses of 2-Substituted Quinolines, 1,8-Naphthyridines, and Related Heterocycles》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:20028-53-9).
Catalysts were evaluated on the preparation of 2-substituted quinolines, 1,8-naphthyridines, and chromone derivatives, e.g., I-III, resp., from unmodified Me ketones and o-aminoarom. aldehydes. While oxide catalysts yielded the 2,3-dialkyl substituted products, cyclic secondary amines provided the 2-alkylsubstituted products regioselectively. In particular, pyrrolidine derivatives provided the highest regioselectivity favoring the 2-substituted products. The most reactive and regioselective catalyst was the bicyclic pyrrolidine derivative, TABO (1,3,3-trimethyl-6-azabicyclo[3.2.1]octane), yielding 1,8-naphthyridines with as high as 96:4 regioselectivity. Regioselectivity increased with slow addition of the Me ketone substrate to the reaction mixture, and was pos. related to temperature Isolated yields of single regioisomers were typically 65-84%, while observed regioselectivities were ≥90:10 for 1,8-naphthyridines and ≥84:16 for quinolines.
When you point to this article, it is believed that you are also very interested in this compound(20028-53-9)Safety of 2-Amino-5-chlorobenzaldehyde and due to space limitations, I can only present the most important information.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem