Bhoir, Indravadan C.; Raman, Bhanu; Sundaresan, M.; Bhagwat, Ashok M. published the article 《Separation and estimation of seven vasodilators using packed column supercritical fluid chromatography》. Keywords: supercritical fluid chromatog vasodilator determination.They researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1028-33-7) here.
This paper reports a method for an isocratic separation and simultaneous estimation of 7 vasodilators: isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), cyclandelate, nimodipine, amlodipine, pentifylline and pentoxifylline using packed column supercritical fluid chromatog. (SFC). An arbitrary choice of vasodilatory compounds with respect to their chem. structures was made to examine the viability of this technique for anal. of drugs and pharmaceuticals. Elution was performed on a RP-C18 column. SFC offers several degrees of freedom: temperature, pressure and modifier concentration to attain optimum resolution and sensitivity. The effects of these parameters on retention time were studied by using methanol modified carbon dioxide. The analytes were identified and measured by UV-detection. The chromatog. points of merit have been listed. Detection limits appear to be similar to those found in liquid chromatog. Modifier concentration does generally make major changes in retention and selectivity. A full scale validation for the seven vasodilators has been attempted and the statistical quality evaluated.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem