Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4221-99-2, is researched, Molecular C4H10O, about Synthesis and application of methyl itaconate-anthracene adducts in configuration assignment of chiral secondary alcohols by 1H NMR, the main research direction is methyl itaconate anthracene preparation secondary alc absolute configuration detection.Reference of (S)-Butan-2-ol.
Novel chiral derivatizing agents (CDAs) such as Me itaconate-anthracene adducts (MIAs) I and II were reported for the absolute configuration determination of chiral secondary alcs. e.g., S-1-phenyl-1-ethanol by the 1H NMR technique. These adducts I and II were facilely prepared through well-known reactions, and furthermore, com. available starting materials. According to these synthetic routes, the desired MIAs I and II were afforded in 6 steps with 49% overall yield from di-Me itaconate III. Moreover, the represented MIAs provided significantly large differences of chem. shift values (δδSR). No racemization from the tertiary characteristics of the adjacent alpha carbon was observed
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem