Formula: C7H6ClNO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of α-amylase and α-glucosidase. Author is Shamim, Shahbaz; Khan, Khalid Mohammed; Ullah, Nisar; Chigurupati, Sridevi; Wadood, Abdul; Ur Rehman, Ashfaq; Ali, Muhammad; Salar, Uzma; Alhowail, Ahmad; Taha, Muhammad; Perveen, Shahnaz.
(E)-3-(2-Benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs I (R = 4-ClC6H4, 2-Cl-5-O2NC6H3, furan-2-yl, etc.) were synthesized by multi-step reaction scheme and subjected to in vitro inhibitory screening against α-amylase and α-glucosidase enzymes. All compounds exhibited good to moderate inhibitory potential in terms of IC50 values ranging (IC50 = 13.02 +/- 0.04-46.90 +/- 0.05μM) and (IC50 = 13.09 +/- 0.08-46.44 +/- 0.24μM) in comparison to standard acarbose (IC50 = 12.94 +/- 0.27μM and 10.95 +/- 0.08μM), for α-amylase and α-glucosidase, resp. Structure-activity relationship indicated that analogs with halogen substitution(s) were found more active as compared to compounds bearing other substituents. Kinetic studies on most active α-amylase and α-glucosidase inhibitors I (R = 4-ClC6H4, 2,4-di-ClC6H3, 4-F3CC6H4, 2-Cl-5-O2NC6H3, 3-MeO-4-F-C6H3, furan-2-yl, etc.) suggested non-competitive and competitive types of inhibition mechanism for α-amylase and α-glucosidase, resp. Mol. docking studies predicted the good protein-ligand interaction (PLI) profile with key interactions such as arene-arene, H-<, <-<, and <-H etc., against the corresponding targets. There is still a lot of research devoted to this compound(SMILES：NC1=CC=C(Cl)C=C1C=O)Formula: C7H6ClNO, and with the development of science, more effects of this compound(20028-53-9) can be discovered.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem