Product Details of 20028-53-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Antiproliferative activity of new 2-glyco-3-nitro-1,2-dihydroquinolines and quinolines synthesized under solventless conditions promoted by neutral alumina. Author is Luque-Agudo, V.; Padron, Jose M.; Roman, E.; Serrano, J. A.; Gil, M. V..
This paper describes the syntheses of new 2-glyco-3-nitro-1,2-dihydroquinolines and 2-glyco-3-nitroquinolines by one-pot aza-Michael-Henry-dehydration reactions using a minimal amount of solvent and neutral alumina as the heterogeneous catalyst. The reactivity of the nitro group-double bond system has also been investigated; thus, the addition of indole or pyrrole to N-formylated 1,2-dihydroquinolines has been studied. Finally, the cytotoxicity and antiproliferative activity of these new compounds have been evaluated against a panel of six human solid tumor cell lines and compared to pharmacol. reference compounds, finding that their activity is in the low micromolar range and that the carbohydrate moiety configuration modulates the GI50 values.
In some applications, this compound(20028-53-9)Product Details of 20028-53-9 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem