In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Ru(III)-catalyzed construction of variously substituted quinolines from 2-aminoaromatic aldehydes (ketones) and isoxazoles: Isoxazoles as cyclization reagent and cyano sources, published in , which mentions a compound: 20028-53-9, mainly applied to aminoarom carbonyl compound isoxazole ruthenium catalyst cyclization; cyanoquinoline preparation green chem, HPLC of Formula: 20028-53-9.
A Ru(III)-catalyzed annulation reaction of 2-aminoarom. aldehydes (ketones) and isoxazoles to afford diverse 3-cyanoquinolines was developed. Notably, isoxazole acted as a cyclization reagent and nontoxic cyano source via N-O bond cleavage and fragmentation. Variously substituted (especially 6- or 7-substituted) quinolines could be easily afforded. This procedure featured wide functional group compatibility, efficiency and avoiding toxic cyano source. Meanwhile, this protocol could be successfully applied to scale-up synthesis. Further chem. transformations of 3-cyanoquinoline could give some valuable skeletons, demonstrating its potential in synthetic application.
If you want to learn more about this compound(2-Amino-5-chlorobenzaldehyde)HPLC of Formula: 20028-53-9, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(20028-53-9).
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem