With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
General procedure: A mixture of the above intermediates (8, 9, 10 or 11), 2,2-dimethylsuccinic anhydride (10 equiv) and DMAP (1 equiv) in anhydrous pyridine (20 mL/mmol) was refluxed overnight. The mixture was then concentrated under vacuum and the residue was chromatographed on silica gel to yield the derivatives 12, 13, 14 and 15., 17347-61-4
As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.
Reference£º
Article; Coric, Pascale; Turcaud, Serge; Souquet, Florence; Briant, Laurence; Gay, Bernard; Royer, Jacques; Chazal, Nathalie; Bouaziz, Serge; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 453 – 465;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem