118399-28-3, (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(R)-Benzyl 5 -oxo-tetrahydrofuran-3 -ylcarbamate (24 g, 0.1 mol) was added to the solution ofMe2NH (45 g, 1 mol) in CH2Cl2 (500 ml). The mixture was stirred overnight. The solid was collected by filtration. Toluene (500 mL) was added to dissolve the solid, followed by (PhS)2 (32.7 g, 0.15 mol) and Bu3P (40 g, 0.2 mol). The mixture was heated to 80C and stirred for 18 h. The solvent was removed in vacuo. The residue was subjected to flash column chromatography on silica gel eluting with 50% EtO Ac/petroleum ether to provide 0123 (13.4 g, 35.3%). LC-MS: 373 [M+l]+. 1H NMR (CDCl3):delta 2.46 (m, 1H), 2.82 (s, 3H), 2.84 (s, 3H), 2.88 (m, 1H), 3.20 (m, 1H), 3.33 (m, 1H), 4.13 (m, 1H), 5.07 (s, 2H), 6.30 (d, J= 9.0 Hz, 1H), 7.15 (m, 1H), 7.32 (m, 9H).
118399-28-3, The synthetic route of 118399-28-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CURIS, INC.; WO2009/36035; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem