Application of 52449-98-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 52449-98-6, Name is Oxolane-2-carbonyl chloride, molecular formula is C5H7ClO2. In a Article，once mentioned of 52449-98-6
A series of quinazoline derivatives, 2-20, structurally related to the racemic alpha1-adrenoceptor antagonist cyclazosin (1), were synthesized and evaluated for their functional antagonism at alpha1- and alpha2-adrenoceptors and for their binding affinity at human cloned alpha1a-, alpha1b- and alpha1d-adrenoceptor subtypes. They displayed, like 1, preferential antagonism and selectivity for alpha1 versus alpha2-adrenoceptors. Compounds 10, 13, and 18 showed high potency at alpha1-adrenoceptors similar to that of 1 (pKB values 8.47-8.89 versus 8.67), whereas 13 and 15 were endowed with the highest alpha1-adrenoceptor selectivity, only 3- to 4-fold lower than that of 1. In binding experiments, all of the compounds displayed an affinity practically similar to that found for 1, with the exception of 19 and 20 that were definitely less potent. The s-triazine analogue 18 was the most potent of the series with pKi values of 10.15 (alpha1a), 10.22 (alpha1b) and 10.40 (alpha1d), resulting 77-fold more potent than 1 at alpha1a-adrenoceptors. In addition, the majority of compounds, like prototype 1, showed the same trend of preferential affinity for alpha1d- and alpha1b-adrenoceptors that alpha1a-subtype. In conclusion, we identified compounds 2-5, 10, 12 and 13, bearing either an aliphatic- or an arylalkyl- or aryloxyalkyl-acyl function, with an interesting subtype-selectivity profile, which makes them suitable candidates for their resolution as enantiomers structurally related to (+)-cyclazosin.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 52449-98-6. In my other articles, you can also check out more blogs about 52449-98-6
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem