One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C5H10O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol, molecular formula is C5H10O2
This letter describes the further chemical optimization of VU0424238 (auglurant), an mGlu5 NAM clinical candidate that failed in non-human primate (NHP) 28 day toxicology due to accumulation of a species-specific aldehyde oxidase (AO) metabolite of the pyrimidine head group. Here, we excised the pyrimidine moiety, identified the minimum pharmacophore, and then developed a new series of saturated ether head groups that ablated any AO contribution to metabolism. Putative back-up compounds in this novel series provided increased sp3 character, uniform CYP450-mediated metabolism across species, good functional potency and high CNS penetration. Key to the optimization was a combination of matrix and iterative libraries that allowed rapid surveillance of multiple domains of the allosteric ligand.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C5H10O2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 15833-61-1, in my other articles.
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem