With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.
To a solution of 2-formyl-4,5 -dimethyl-6-(5 -((1 -methylcyclopropyl)methoxy)-2-azabicyclo[4. 1 .Ojheptan-2-yl)nicotinonitrile (compound 5-4 of Scheme 5, 100 mg, 0.295 mmol) in DCE (3 mL) was added tetrahydrofuran-3-amine (25.7 mg, 0.295 mmol) and AcOH (1.687 tL, 0.029 mmol), the mixture was stirred at 40 ¡ãC for 0.5 h. Then sodium triacetoxyborohydride (125 mg, 0.589 mmol) was added and the mixture was stirred at 40 ¡ãC for 16 h. The reactionmixture was quenched with saturated aqeous NaHCO3 (1 0 mL) and the mixture was extracted with EtOAc (10 mL x 3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to get the residue, which was further purified by pre-TLC (DCM:MeOH = 10:1) to give the title compound., 88675-24-5
The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP and DOHME CORP.; CLAUSEN, Dane James; FELLS, James, I.; KOZLOWSKI, Joseph, A.; LIU, Ping; MAZZOLA, Robert, D., Jr.; (94 pag.)WO2018/226545; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem