97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of (R)-(tetrahydrofuran-2-yl)methanol (2.0 g, 19.6 mmol) and di-tert-butyl hydrazine-1,2-dicarboxylate (4.5 g, 19.6 mmol) in anhydrous tetrahydrofuran (60 mL) was added triphenylphosphine (7.2 g, 27.4 mmol) followed by di-tert-butyl azodicarboxylate (6.3 g, 27.4 mmol) portionwise. The mixture was stirred for 16 hours, concentrated under reduced pressure and the crude residue purified by flash column chromatography using ethyl acetate, hexane (1:19 to 1:4) as an eluent to obtain the title compound (4.5 g, 72%), as a white solid, mp: 78.8-82.3 C; Rf: 0.19 (1:4 ethyl acetate, hexane); IR (vmax (neat)): 3314, 3254, 2831, 1737, 1661, 1229, 1144 cm-1; 1H NMR (300 MHz, CDCl3): delta 1.45 (18H, s), 1.78-1.99 (4H, m), 3.29-3.66 (2H, m), 3.67-3.91 (2H, m), 4.00-4.16 (1H, m), 6.58 (1H, bs) ppm; 13C NMR (75 MHz, CDCl3): delta 25.6, 28.3, 29.1, 53.3, 68.0, 74.1, 81.1, 155.4 ppm; LRMS (+ESI) m/z: 339.2 ([M+Na]+ 100%)., 97-99-4
The synthetic route of 97-99-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Moir, Michael; Boyd, Rochelle; Gunosewoyo, Hendra; Montgomery, Andrew P.; Connor, Mark; Kassiou, Michael; Tetrahedron Letters; vol. 60; 36; (2019);,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem