Discovery of 4,4-Dimethyldihydrofuran-2,3-dione

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Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 4,4-Dimethyldihydrofuran-2,3-dione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 13031-04-4

THE ASYMMETRIC HYDROGENATION OF alpha-KETO ESTERS CATALYZED BY RHODIUM(I) COMPLEXES WITH CHIRAL DIPHOSPHINE LIGANDS. ON THE CATALYTIC CYCLES AND THE MECHANISM OF ASYMMETRIC INDUCTION

Asymmetric hydrogenations of n-propyl pyruvate and ketopantoyl lactone catalyzed by rhodium complexes with (-) DIOP and BPPM were carried out under a variety of conditions.It was found that i) the Schrock-Osborn mechanism was not operative in these reactions at all since no acceleration of the reaction rate by the addition of water (1percent) was observed, ii) there was a clear difference between cationic and neutral (in situ) rhodium catalysts in their enantioslectivity, and iii) there was a remarkable solvent effect on the extent and direction of asymmetric induction.Possible mechanisms are discussed on the basis of these results.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem