17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
17347-61-4, Example 23: Preparation of 4-(((lS,3aS,5aR,5bR,7aR,9S, l laR,l lbR,13aR,13bR)-3a-((S)-2- (5-(4-fluorophenyl)- lH-imidazol-2-yl)pyrrolidine-l -carbonyl)- 1 -isopropyl-5a,5b,8,8, 11 a- pentamethylicosahydro-lH-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid: [0205] To a stirred solution of ((S)-2-(5-(4-fluorophenyl)-lH-imidazol-2- yl)pyrrolidin-l -yl)(( 1 S,3aS,5aR,5bR,7aR,9S, 11 aR, 1 IbR, 13aR, 13bR)-9-hydroxy- 1 -isopropyl- 5a,5b,8,8, 11 a-pentamethylicosahydro-3aH-cyclopenta[a]chrysen-3a-yl)methanone (Example 22-step 2, 0.15 g, 0.22 mmol) and 2,2-dimethyl succinicanhydride (0.12 g, 0.8 mmol) in toluene (8 mL) was added DMAP (0.06 g, 0.44 mmol). The reaction mixture was heated at 90¡ãC for 12 hours. After completion of the reaction (monitored by TLC), the reaction mixture was concentrated under reduced pressure, cooled to 0¡ãC, acidified to pH = 6 with IN HC1 and extracted with DCM. The combined organic extracts was washed with water, brine, dried over Na2S04, then the solvent was evaporated and to the resulting solid was recrystalised from ACN to give the title compound (0.08 g, Yield 47percent) as a white solid. 1H-NMR (CDC13, 300 MHz): delta 7.57 (m, 2H), 7.15 (s, 1H), 7.03 (t, J = 6.9 Hz, 2H), 5.35- 5.32 (m, 1H), 4.54- 4.48 (m, 1H), 3.71- 3.69 (m, 1H), 3.55 (m, 1H), 2.97- 2.93 (m, 2H), 2.71- 2.60 (m, 3H), 2.29- 1.13 (m, 36H), 0.99- 0.82 (m, 15H), 0.73 (d, J = 6.6 Hz, 3H); ESI MS: 800.5 (M+H).
17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA REDDY, Adulla; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; VL SUBRAHMANYAM, Lanka; DAVID KRUPADANAM, Gazula, Levi; VENKATI, Mukkera; SUDHAKAR, Neela; SRINIVAS REDDY, Kallem; WO2014/105926; (2014); A1;,
Tetrahydrofuran – Wikipedia
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