With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.124391-75-9,(S)-(Tetrahydrofuran-3-yl)methanol,as a common compound, the synthetic route is as follows.
To a mixture of 25 g of ( tetrahydrofuran-3-yl ) methanol of the following formula:and 125 ml of pyridine, 56 g of p-toluenesulfonyl chloride was added under nitrogen atmosphere and under ice-cooling, and stirred for 4 hours under ice-cooling. To the reaction mixture, water was added and extracted with tert-butyl methyl ether 2 times. The organic layer was washed with 1 mol/1 of hydrochloric acid and brine successively. The organic layer was dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure to obtain 58 g of a crude product of p- toluenesulfonic acid tetrahydrofuran-3-ylmethyl ester of the following formula.The crude product was used for Reference Production Example 2 without further purification., 124391-75-9
124391-75-9 (S)-(Tetrahydrofuran-3-yl)methanol 40784875, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MATSUO, Noritada; OHSHITA, Jun; WO2012/133861; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem