165253-29-2, Name is 3-(Bromomethyl)tetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. SDS of cas: 165253-29-2In an article, once mentioned the new application about 165253-29-2.
Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes
TGR5 is a member of G protein-coupled receptor (GPCR) superfamily, a promising molecular target for metabolic diseases. Activation of TGR5 promotes secretion of glucagon-like peptide-1 (GLP-1), which activates insulin secretion. A series of 2-thio-imidazole derivatives have been identified as novel, potent and orally efficacious TGR5 agonists. Compound 4d, a novel TGR5 agonist, in combination with Sitagliptin, a DPP-4 inhibitor, has demonstrated an adequate GLP-1 secretion and glucose lowering effect in animal models, suggesting a potential clinical option in treatment of type-2 diabetes.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 165253-29-2
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem