22929-52-8, Dihydrofuran-3(2H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 164 Ethyl 3-[[(trans-4-methylcyclohexyl)carbonyl](tetrahydro-3-furanyl)amino]-1- (phenylmethyl)-1 ate To a solution of Intermediate 163 (3.73 g, 11.8 mmol) in DCM (35 mL) was added trans-4- methylcyclohexanecarbonyl chloride (2.28 g, 14 mmol), followed by triethylamine (2.5 mL). The reaction was heated at 45 ¡ãC for 16 hours under nitrogen, whereupon further aliquots of triethylamine (2 mL) and trans-4-methylcyclohexanecarbonyl chloride (1.5 g) were added. Heating was continued for a further 16 hours. After cooling, the mixture was diluted with DCM, washed with hydrochloric acid solution (1M), then water, and then saturated sodium bicarbonate solution. The organic layer was passed through a hydrophobic frit, evaporated, and purified using 120 g ISCO Flash column, eluting with a gradient of ethyl acetate in cyclohexane (5-100percent) to give the title compound. MS calcd for (C25H33N304+ H) + : 440 MS found (electrospray) : (M+H) += 440
22929-52-8, As the paragraph descriping shows that 22929-52-8 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/92863; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem