Chemistry is traditionally divided into organic and inorganic chemistry. name: (Tetrahydrofuran-3-yl)methanamine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 165253-31-6
A synthetic method of the dinotefuran (by machine translation)
The invention discloses a method for synthesis of dinotefuran, to gamma – butyrolactone as raw materials, by Aldol condensation, also the original two-step by the reaction of 3 – hydroxy methyl tetrahydrofuran, then by the Gabriel synthesis of 3 – tetrahydrofuran methyl amine, dimethyl carbonate (DMC) as methylation reagent with the urea synthesis O – methyl isourea, re-nitration synthetic O – methyl – N – nitro-isourea, then with the methylamine reaction synthesis of 1, 3 – dimethyl – 2 – nitro-isourea, final 3 – tetrahydrofuran methylamine with 1, 3 – dimethyl – 2 – nitro-isourea through SN2 Bimolecular nucleophilic substitution reaction, one-step synthesis of dinotefuran. The present invention uses non of dimethyl carbonate as the methylating reagent, the methylation reaction yield ? 95%, O – methyl isourea content ? 96%, the by-product is carbon dioxide and methanol, process and environmental protection, the overall yield of the dinotefuran ? 50%. Synthetic method of this invention to reduce the production cost at the same time, with three wastes, after treatment is simple, the advantages of the environment friendly, and is suitable for industrial production, bring about significant economic benefits. (by machine translation)
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem