5061-21-2, 2-Bromo-4-butanolide is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5061-21-2, alpha-Bromo-gamma-butyrolactone (1) (925 mul, 10 mmol, 1 equiv) was dissolved in acetone (17 ml) and a solution of NaN3 (3.25 g in 7 ml H2O, 50 mmol, 5 equiv) was added. The resulting solution was stirred overnight. Acetone was removed by evaporation under reduced pressure. The resulting aqueous mixture was extracted with CH2Cl2 (2 ¡Á 50 mL) and the organic layers were combined, dried over Na2SO4, filtered, and evaporated under reduced pressure. The resulting oil was found to be pure by NMR analysis (and was used without further purification). 1H NMR (300 MHz, CDCl3): delta 4.42 (dt, 1H, J = 3.6 Hz and 8.9 Hz, H-3), 4.23-4.31 (m, 2H, H-3 and H-1), 2.50-2.61 (m, 1H, H-2), 2.10-2.24 (m, 1H, H-2); 13C NMR (75 MHz, CDCl3): delta 173.6, 66.0, 56.8, 29.1
5061-21-2 2-Bromo-4-butanolide 95463, aTetrahydrofurans compound, is more and more widely used in various.
Reference£º
Article; Brackman, Gilles; Risseeuw, Martijn; Celen, Shari; Cos, Paul; Maes, Louis; Nelis, Hans J.; Van Calenbergh, Serge; Coenye, Tom; Bioorganic and Medicinal Chemistry; vol. 20; 15; (2012); p. 4737 – 4743;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem