Application of 108-30-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 108-30-5, Name is Dihydrofuran-2,5-dione, SMILES is O=C(CC1)OC1=O, belongs to tetrahydrofurans compound. In a article, author is Yaragani, Muralikrishna, introduce new discover of the category.
Design and synthesis of novel tetrahydrofuran cyclic urea derivatives as androgen receptor antagonists
In order to improve the antiproliferative activity of androgen receptor (AR) antagonists, which used clinically for the treatment of prostate cancer that is a major cause of male death in worldwide, we report the design and synthesis of a series of tetrahydrofuran cyclic urea-based non-steroidal small molecule AR antagonists and exhibit potent AR antagonistic activity. These molecules with higher stereochemical aspects have been achieved by changing the hydantoin analogue antiandrogens to 4-(2-oxohexahydro-1H-furo[3,4-d] imidazol-1-yl)-2-(trifluoromethyl)benzonitrile analogues. Here, the thio-hydantoin pharmacophore of the recently reported antagonists is replaced by tetrahydrofuran cyclic urea. The antiproliferative properties of these molecules have been evaluated against androgen-dependent (LNCaP) cell line. Among the reported molecules, 4-(2-oxohexahydro-1H-furo[3,4-d]imidazol-1-yl)-2-(trifluoromethyl)benzonitrile (AR04) showed significantly improved in vitro activity, IC50= 3.926 mu M. Molecular structure-activity relationship studies confirm that the oxetane analogueAR04is distinct from other synthesized AR antagonists. These results have suggested thatAR04exhibiting their potential as a lead compound for the alternative treatment of prostate cancer.
Application of 108-30-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 108-30-5 is helpful to your research.
Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem