Chemistry, like all the natural sciences, Application In Synthesis of 3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one, begins with the direct observation of nature¡ª in this case, of matter.79-50-5, Name is 3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one, SMILES is O=C1OCC(C)(C)C1O, belongs to Tetrahydrofurans compound. In a document, author is Vichare, V. S., introduce the new discover.
SIMULTANEOUS ESTIMATION OF DAPSONE AND ADAPALENE IN GEL FORMULATION BY UV- SPECTROSCOPY
Objective: A new, simple, sensitive, and economical UV spectrophotometric method was developed for the simultaneous analysis of Adapalene and Dapsone in pharmaceutical formulation. Method: This UV method was developed with Tetrahydrofuran and Distilled water as solvents. The wavelengths selected for analysis in the present method were 237 nm and 293 nm. The method was validated as per ICH guidelines. Results: The method was validated for linearity, accuracy, precision, specificity and robustness. Linearity was found to be within the concentration range of 0.05-0.25 mu g/ml for Adapalene and 2.5-12.5 mu g/ml for Dapsone. Accuracy for the method was determined by recovery studies. The % drug recovered was found to be 99-102% w/w. The % RSD values of repeatability and intermediate precision were found to be less than 2, providing method was precise in nature. From all these studies it was observed that there was no interference of excipients from the formulation during the analysis. Conclusion: The advantages of this method for analytical purposes lie in the rapid determination, its cost-effectiveness, easy preparation of the sample and good reproducibility. In addition to this, the present method can be recommended for the simultaneous determination of Adapalene and Dapsone in routine quality control analysis in combined drug formulations.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 79-50-5. Application In Synthesis of 3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one.
Reference:
Tetrahydrofuran – Wikipedia,
,Tetrahydrofuran | (CH2)3CH2O – PubChem