Extracurricular laboratory:new discovery of (Tetrahydrofuran-3-yl)methanamine

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Synthetic Route of 165253-31-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.165253-31-6, Name is (Tetrahydrofuran-3-yl)methanamine, molecular formula is C5H11NO. In a article£¬once mentioned of 165253-31-6

A dinotefuran intermediate 3 – amino methyl tetrahydrofuran preparation method (by machine translation)

The invention relates to a kind of dinotefuran intermediate 3 – amino methyl tetrahydrofuran preparation method, specifically it is to cyano acetic acid ester as the raw material, first with 1, 2 – dihalo ethane condensation reaction to obtain the intermediate 2 – halogenated ethyl – 2 – cyano – acetate, followed by a further reduction to obtain intermediate 2 – halogenated ethyl – 2 – cyano – ethanol, then intermediate 2 – halogenated ethyl – 2 – cyano – ethanol cyclization to obtain intermediate 3 – cyano tetrahydrofuran; the final 3 – cyano tetrahydrofuran obtained by catalytic hydrogenation of dinotefuran intermediate 3 – amino methyl tetrahydrofuran. Preparation method of the invention, raw materials are easy, simple operation, low production cost, and thus is suitable for industrial production. (by machine translation)

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem