19311-37-6, Name is 3-Bromotetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. Quality Control of 3-BromotetrahydrofuranIn an article, once mentioned the new application about 19311-37-6.
Process for the preparation of a 3-substituted thio-3-cephem compound
An ester of 7-acylamido-3-acylthio-3- or -2-cephem-4-carboxylic acid represented by general formula (1) STR1 wherein R1 is an acyl group, R2 is a carboxyl-protecting group, R3 is a lower alkyl group, an aryl group or a substituted aryl group, or a mixture of two or more of said ester is used as the starting compound and is reacted wit a tertiary amine and also a secondary amine. Then the tertiary amine salt compound as formed as the reaction product is reacted with a compound of formula (4) wherein R4 is a lower alkyl group, a cycloalkyl group or a heterocyclic group or a heterocyclic group-substituted methyl group and X is a leaving group, whereby the desired ester of 7-acylamido-3-substituted thio-3-cephem-4-carboxylic acid of formula (5) STR2 can be produced preferentially, conveniently and efficiently.
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem