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Intramolecular Cyclization of Some Unsaturated Alcohols by Means of Thallium Triacetate
Reactions of some primary and secondary Delta4-, Delta5- and Delta6-alkenols with thallium triacetate (TTA) in benzene, acetic acid and chloroform as solvent have been investigated.When terminally unsubstituted Delta4-alkenols, such as 4-penten-1-ol (5a) and 5-hexen-2-ol (5b), are treated with TTA in benzene, beta-acetoxylated tetrahydrofurans 8a and 8b are obtained.However, when the reaction is carried in acetic acid the products are both regioisomers, i.e. five- and six-membered cyclic ethers (8a, 8b, 7a and 7b). 4-Methyl-4-penten-1-ol (5c) is converted in benzene into a mixture of products (8c and 7c) in which the tetrahydropyran derivative 7c is predominant, and in acetic acid it is the sole cyclization product.Terminally dialkylated alkenols, such as 5-methyl-4-hexen-1-ol (1b) and 6-methyl-5-hepten-2-ol (1c), are converted into beta-acetoxylated (4b and 4c) and unsaturated cyclic ethers (9a and 9b), in both cases of the tetrahydrofuran type. 5-Hexen-1-ol (10) and 6-hepten-1-ol (11) cyclize to the corresponding six- (13) and seven-membered cyclic ether (14), respectively.Organothallium intermediates have been isolated and identified in the cases of alcohols 5a, 5c and 10, proving that the TTA addition to the double bond has originally obeyed the Markovnikov rule. Key Words: Alcohols, unsaturated / Thallium triacetate
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem