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Syntheses of xanthofulvin and vinaxanthone, natural products enabling spinal cord regeneration

Growth promoting: The first synthesis of the natural product xanthofulvin (SM-216289) has resolved issues regarding its structural assignment and that described for the natural product 411J. The structurally and biologically related natural product vinaxanthone was similarly prepared through a novel dimerization reaction. Treatment of C. elegans with synthetic xanthofulvin and vinaxanthone enhanced axonal branching.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem