88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,88675-24-5
EXAMPLE 44: (2i?)-2-(6-fluoro-3-oxopyrrolo[4,3,2-Je][2,6]naphthyridin- 4(l/f,3/f,5H)-yl)-3-methyl-Lambda/-(tetrahydrofuran-3-yl)butanamide[0410] To an 8 mL scintillation vial equipped for stirring was added (i?)-2-(6-fluoro-3- oxopyrrolo[4,3,2-(ie][2,6]naphthyridin-4(lH,3H,5H)-yl)-3-methylbutanoic acid (15 mg, 0.051 mmol). DMF (0.5 mL), tetrahydrofuran-3 -amine (0.077, 6.7mg), HOBt (11.83 mg, 0.077 mmol), EDC (14.81 mg, 0.077 mmol) and N,N-dimethylpyridin-4-amine (9.44 mg, 0.077 mmol) were added and the solution was stirred at 25¡ãC for 4 h. The reaction mixture was purified via preparative mass trigger LC-MS (AcCN/H2O, 20-50percent). The fractions were collected and lyophilized to afford the title compound as a white solid (7.3mg, 39.3percent). 1H NMR (400 MHz, CD3OD) delta 0.93 (d, J=6.57 Hz, 3 H) 1.04 (dd, J=6.57, 2.78 Hz, 3 H) 1.74 -1.95 (m, 1 H) 2.21 (d, J=7.83 Hz, 1 H) 2.42 – 2.54 (m, 1 H) 3.50 – 3.67 (m, 1 H) 3.69 – 3.97 (m, 3 H) 4.37(td, J=3.85, 1.89 Hz, 1 H) 4.96 – 5.12 (m, 2 H) 5.36 – 5.52 (m, 1 H) 7.86 (s, 1 H) 8.17 (d, J=3.28 Hz, 1 H). [M+H] calc’d for Ci8H2IFN4O3, 361; found, 361.4.
As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; LAWSON, John, David; WALLACE, Michael, B.; KANOUNI, Toufike; WO2010/144486; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem