453-20-3, Name is 3-Hydroxytetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. Safety of 3-HydroxytetrahydrofuranIn an article, once mentioned the new application about 453-20-3.
Direct Calpha-heteroarylation of structurally diverse ethers: Via a mild N -hydroxysuccinimide mediated cross-dehydrogenative coupling reaction
An important challenge in the Calpha-heteroarylation of ethers is the requirement of a large excess amount of ethers (that are used as solvents in many cases) to achieve effective transformations. This drawback has significantly restricted the Calpha-heteroarylation of ethers to the use of simple and easily accessible ether substrates. To overcome this limitation, a new, efficient, N-hydroxysuccinimide (NHS) mediated, mild and metal-free CDC strategy for the direct Calpha-heteroarylation of diverse ethers has been developed. Different to our previous benzaldehyde mediated photoredox Calpha-heteroarylation, we have identified NHS as a new and efficient mediator without using light. A distinct non-photoredox engaged hydrogen-atom-transfer (HAT) mechanism that used a nitrogen-centered radical cation produced from NHS is initially revealed. Notably, only 5-10 equivalents of ethers as coupling partners are used, which allows for structurally diverse and complex ethers to engage in this process, to create highly medicinally relevant Calpha-heteroarylated ethers. Furthermore, more structurally diverse heterocyclics can serve as reactants for this process.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 453-20-3
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem