In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 17347-61-4, name is 2,2-Dimethylsuccinicanhydride, introducing its new discovery. SDS of cas: 17347-61-4
Synthesis of Chiral gamma-Lactams via in Situ Elimination/Iridium-Catalyzed Asymmetric Hydrogenation of Racemic gamma-Hydroxy gamma-Lactams
Chiral gamma-lactams have been synthesized in excellent yields and enantioselectivities (up to 99% yield and 96% ee) from easily accessible racemic gamma-hydroxy gamma-lactams via an iridium-phosphoramidite catalyzed asymmetric hydrogenation. The reaction was designed based on insight into the reaction mechanism demonstrated in previous work and can be carried out at a reduced catalyst loading of 0.1 mol % on a gram scale. Several potential bioactive compounds can be synthesized from the reduced products. Mechanistic studies indicated that the reduced products were obtained via the hydrogenation of the N-acyliminium cations, generated from gamma-hydroxy gamma-lactams.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 17347-61-4, and how the biochemistry of the body works.SDS of cas: 17347-61-4
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem