915095-87-3, Name is (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone, belongs to Tetrahydrofurans compound, is a common compound. Computed Properties of C17H14ClIO3In an article, once mentioned the new application about 915095-87-3.
Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent
A series of halogenated Phenstatin analogs were designed as microtubule destabilizing agent by docking study. It was synthesized within three steps starting from 2-chloro-5-iodobenzoic acid and substituted benzene. All the products were characterized by 1H NMR and 13C NMR spectral analysis, and the stereochemical structure was also confirmed by a single crystal X-ray diffraction crystallographic analysis. The microtubule destabilizing activities were evaluated in vitro with human liver cancer Huh-7 cell line and human lung cancer A549 cell line. Some of the HPAs were achieved IC50 about 5.0 muM against human liver cancer Huh-7 cells. [Figure not available: see fulltext.].
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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem