A new application about Ethyl 2-oxotetrahydrofuran-3-carboxylate

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Reference of 77513-58-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 77513-58-7, molcular formula is C7H10O4, introducing its new discovery.

Azidation of beta-carbonyl lactones and lactams

The direct azidation of various heterocyclic beta-ketoesters, lactones, and lactams is reported. By using tosylazide and an organic base such as l-proline or TBD, the direct alpha-insertion of azide into these substrates was achieved in moderate to good yields, without competitive deacylating diazo transfer. This procedure represents an interesting alternative to the usual two-step approach of alpha-halogenation and subsequent displacement with azide ion.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem