Electric Literature of 453-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.453-20-3, Name is 3-Hydroxytetrahydrofuran, molecular formula is C4H8O2. In a Article£¬once mentioned of 453-20-3
ANALOGS OF PYRIMIDINE NUCLEOSIDES. 15. SYNTHESIS OF 3′-HYDROXY- AND 4′-HYDROXYFTORAFUR
A method for the synthesis of ftorafur metabolites, viz., 3′-hydroxy- and 4′-hydroxyftorafur, from 3-benzoxytetrahydrofuran, which is chlorinated in the presence of UV irradiation, was developed.The resulting mixture of alpha-chloro ethers is alkylated by 2,4-bis(trimethylsilyl)-5-fluorouracil.The alkylation products are separated by fractional crystallization and column chromatography on silica gel, and the benzoyl protective group is removed. cis-4′-Hydroxyftorafur, trans-3′-hydroxyftorafur, and cis-3′-hydroxyftorafur, which were identified from the PMR spectra and by comparison with the literature data, were obtained.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 453-20-3, and how the biochemistry of the body works.Electric Literature of 453-20-3
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem