42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To a solution of 4-(5-(substituted phenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (0.53mmol)in 10mL DCM was added methyl glycinate hydrochloride (0.80mmol), acetic acid (2.12mmol), and N,N-diisopropylethylamine (0.80mmol), and 10mL MeOH. After the reaction was stirred for 3h, sodium cyanoborohydride (0.53mmol) was added. The reaction mixture was quenched with saturated aqueous NaHCO3 solution and extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4, then filtered and concentrated. The residue was purified by silica gel flash column chromatography (DCM:MeOH=20:1) to afford compound 15-1a?15-3n (except for 15-1l).
The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Liu, Tianqi; Jin, Jing; Chen, Yonghui; Xi, Qiumu; Hu, Jinping; Jia, Wenqiang; Chen, Xiaoguang; Li, Yan; Wang, Xiaojian; Yin, Dali; Bioorganic Chemistry; vol. 82; (2019); p. 41 – 57;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem