On the thermodynamic equilibrium between (R)-2-hydroxyacyl-CoA and 2-enoyl-CoA was written by Parthasarathy, Anutthaman;Buckel, Wolfgang;Smith, David M.. And the article was included in FEBS Journal in 2010.Synthetic Route of C5H6O4 This article mentions the following:
A combined exptl. and computational approach has been applied to investigate the equilibrium between several α-hydroxyacyl-CoA compounds and their 2-enoyl-CoA derivatives In contrast to those of their β, γ and δ counterparts, the equilibrium for the α-compounds are relatively poorly characterized, but qual. they appear to be unusually sensitive to substituents. Using a variety of techniques, we have succeeded in measuring the equilibrium constants for the reactions beginning from 2-hydroxyglutaryl-CoA and lactyl-CoA. A complementary computational evaluation of the equilibrium constants shows quant. agreement with the measured values. By examining the computational results, we arrive at an explanation of the substituent sensitivity and provide a prediction for the, as yet unmeasured, equilibrium involving 2-hydroxyisocaproyl-CoA. In the experiment, the researchers used many compounds, for example, (R)-5-Oxotetrahydrofuran-2-carboxylicacid (cas: 53558-93-3Synthetic Route of C5H6O4).
(R)-5-Oxotetrahydrofuran-2-carboxylicacid (cas: 53558-93-3) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Synthetic Route of C5H6O4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem