Month: February 2023

Neuro-ophthalmology of subacute sclerosing panencephalitis: two cases and a review of the literature. was written by Colpak, Ayse I;Erdener, Sefik E;Ozgen, Burce;Anlar, Banu;Kansu, Tulay. And the article was included in Current opinion in ophthalmology in 2012.Application of 36703-88-5 This article mentions the following:

PURPOSE OF REVIEW: To review the literature on early visual manifestations of subacute sclerosing panencephalitis (SSPE) with regard to two patients who had visual problems preceding the onset of neurological symptoms. One patient had cortical visual disturbances and the other had visual loss due to retinal pigment epithelial changes. RECENT FINDINGS: SSPE is a chronic encephalitis characterized by a history of measles infection and a progressive disease of the central nervous system that still occurs frequently in countries with insufficient measles immunization. Visual manifestations can occur as a result of involvement of the pathways that lead from the retina to the occipital cortex during the course of the disease, but are rare as a presenting sign. Fundus changes, especially macular retinitis and macular pigment disturbances, appear to be the most common ocular manifestations of SSPE. SUMMARY: Ophthalmologists must be aware that SSPE can knock their door with ocular findings of SSPE, months or years before the onset of neurological symptoms. In the experiment, the researchers used many compounds, for example, 4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3) (cas: 36703-88-5Application of 36703-88-5).

4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3) (cas: 36703-88-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Application of 36703-88-5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Microbiome-metabolome responses of Fuzhuan brick tea crude polysaccharides with immune-protective benefit in cyclophosphamide-induced immunosuppressive mice was written by Sun, Yujiao;Wang, Fan;Liu, Yang;Liu, Shuai;An, Yuye;Xue, Haiyan;Wang, Jiankang;Xia, Fei;Chen, Xuefeng;Cao, Yungang. And the article was included in Food Research International in 2022.Computed Properties of C10H13N5O5 This article mentions the following:

The present study investigated the immune-protective effect of polysaccharides from Fuzhuan brick tea (FBTPs) in cyclophosphamide (Cy)-induced immunosuppressive mice. The results showed that high-dose of FBTPs administration remarkably alleviated Cy-evoked immune damage through improving the body features, organ indexes, immune responses and oxidative stress in the mice. Further microbiota anal. revealed that FBTPs obviously restored Cy-evoked microbial dysbiosis by increasing several beneficial bacteria Lactobacillus, Allobaculum, Unclassified_f_Lachnospiraceae and norank_f_Lachnospiraceae, while reducing Bacteroides, norank_f_Ruminococcaceae, Colidextribacter, Alloprevotella, norank_f_Desulfovibrionaceae and Helicobacter. Meanwhile, metabolomics anal. found that FBTPs significantly altered a range of microbial metabolites, including inosine, deoxyinosine, taurine, sinapic acid, maltotriose, butyric acid, lysophosphatidyl cholines (LysoPCs), lysophosphatidic acids (LysoPAs) and choline. These altered metabolites were involved in purine metabolism, ABC transporters, sulfur metabolism, neuroactive ligand-receptor interaction, biosynthesis of phenylpropanoids, carbohydrate digestion and absorption, protein digestion and absorption, choline metabolism in cancer and glycerophospholipid metabolism pathways, which were mainly related to immune responses, antioxidant capacity and energy supply of the immunosuppressive mice. Addnl., some significant correlations were observed between the specific microbiota and effective metabolites. These results provide a novel insight into the immune-protective effect of FBTPs on regulating the intestinal microbiota and metabolism, which are helpful for thoroughly understanding the nutrition of FBTPs and providing a solid basis for the deeper utilization of Fuzhuan brick tea (FBT). In the experiment, the researchers used many compounds, for example, 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one (cas: 118-00-3Computed Properties of C10H13N5O5).

2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one (cas: 118-00-3) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Computed Properties of C10H13N5O5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Immunotherapy in patients with local HPV infection and high-grade squamous intraepithelial lesion following uterine cervical conization was written by Kovachev, Stefan Miladinov. And the article was included in Immunopharmacology and Immunotoxicology in 2020.Safety of 4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3) This article mentions the following:

To establish the clearance of cervical human papillomavirus (HPV) infection following postoperative immunotherapy with inosine pranobex in women receiving surgical treatment of established high-grade squamous intraepithelial lesion (HSIL) of the uterine cervix. Over the six-year study period, 32 women with cervical HPV infection following electroconization (loop electrosurgical excision procedure) of the uterine cervix for established HSIL were randomly divided into two groups: I (n = 10) without and II (n = 22) with postoperative inosine pranobex immunotherapy. Follow-up after 24 and 48 mo included cervical testing for HPV persistence and after 12, 24, and 48 mo with cytol. and colposcopy for dysplasia relapse (confirmed histol.). Relapse monitoring in 32 women after 12 mo revealed 1 and 0 HSIL pos. in groups I and II, resp.; after 24 mo an addnl. 3 patients in each group were pos.; and after 48 mo an addnl. 3 and 1 patients were pos. in groups I and II, resp. (p < .05). The groups significantly differed (p < .05) with regard to clearing the most common high-risk HPV genotypes (HPV 16 and HPV 56). Inosine pranobex immunotherapy in HPV-pos. patients following cervical conization significantly increased the clearance of viral infection with high-risk genotypes and reduced relapse of HSIL. In the experiment, the researchers used many compounds, for example, 4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3) (cas: 36703-88-5Safety of 4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3)).

4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3) (cas: 36703-88-5) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Safety of 4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3)

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Matrix-assisted laser desorption/ionization matrices for negative mode metabolomics was written by Fagerer, Stephan R.;Nielsen, Simone;Ibanez, Alfredo;Zenobi, Renato. And the article was included in European Journal of Mass Spectrometry in 2013.Electric Literature of C9H12N3Na2O8P This article mentions the following:

Matrix-assisted laser desorption/ionization (MALDI) has been shown to be highly sensitive for analyzing low-mass compounds such as metabolites if the right matrix is used. 9-Aminoacridine (9AA) is the most commonly employed matrix for neg. mode MALDI-MS in metabolomics. However, matrix interferences and the strongly varying sensitivity for different metabolites make a search for alternative matrixes desirable, in order to identify compounds with a different chem. background and/or favoring a different range of analytes. We tested the performance of a series of potential neg. mode MALDI matrixes with a mix of 29 metabolites containing amino acids, nucleotide phosphates and Krebs cycle intermediates. While ethacridine lactate was found to provide limits of detection (LODs) in the low femtomole range for nucleotide phosphates, amino acids and Krebs cycle intermediates in the low picomole range, 4-amino-2-methylquinoline showed LODs in the picomole range for most metabolites, but is capable of ionizing a broader range of analytes than both 9AA and ethacridine. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Electric Literature of C9H12N3Na2O8P).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C9H12N3Na2O8P

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

2′-C-Methyl Analogs of Selective Adenosine Receptor Agonists: Synthesis and Binding Studies was written by Franchetti, Palmarisa;Cappellacci, Loredana;Marchetti, Stefano;Trincavelli, Letizia;Martini, Claudia;Mazzoni, Maria R.;Lucacchini, Antonio;Grifantini, Mario. And the article was included in Journal of Medicinal Chemistry in 1998.Category: tetrahydrofurans This article mentions the following:

2′-C-Me analogs of selective adenosine receptor agonists such as (R)-PIA, CPA, CCPA, NECA, and IB-MECA were synthesized in order to further investigate the subdomain that binds the ribose moiety. Binding affinities of these new compounds at A₁ and A_2A receptors in bovine brain membranes and at A₃ in rat testis membranes were determined and compared. It was found that the 2′-C-Me modification resulted in a decrease of the affinity, particularly at A_2A and A₃ receptors. When such modification was combined with N⁶-substitutions with groups which induce high potency and selectivity at A₁ receptors, the high affinity was retained and the selectivity was increased. Thus, 2-chloro-2′-C-methyl-N⁶-cyclopentyladenosine (2′-Me-CCPA), which displayed a K_i value of 1.8 nM at A₁ receptors, was selective for A₁ vs A_2A and A₃ receptors by 2166- and 2777-fold, resp., resulting in one of the most potent and A₁-selective agonists so far known. In functional assay, this compound inhibited forskolin-stimulated adenylyl cyclase activity with an IC₅₀ value of 13.1 nM, acting as a full agonist. In the experiment, the researchers used many compounds, for example, (2R,3R,4R,5R)-2-(6-(Cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (cas: 205171-06-8Category: tetrahydrofurans).

(2R,3R,4R,5R)-2-(6-(Cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (cas: 205171-06-8) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Biochemical studies of taste sensation. IX. Enhancement of L-[³H]-glutamate binding to bovine taste papillae by 5′-ribonucleotides was written by Torii, Kunio;Cagan, Robert H.. And the article was included in Biochimica et Biophysica Acta, General Subjects in 1980.COA of Formula: C9H12N3Na2O8P This article mentions the following:

Binding of tritium-labeled L-glutamate [56-86-0] was measured to preparations of bovine circumvallate (taste) papillae (type I preparation) and to control tongue epithelial preparations (type II preparation) devoid of taste receptors. Substantially greater binding occurred to the type I preparation than to the type II preparation, and the binding to the type I preparation showed evidence of saturation The apparent K_d of L-glutamate was 20-30 mM. A several-fold enhancement of binding of L-glutamate-³H occurred in the presence of certain 5′-ribonucleotides. 5′-GMP di-Na salt [5550-12-9], 5′-IMP di-Na salt [4691-65-0], and 5′-UMP di-Na salt [3387-36-8] each increased the binding of L-glutamate-³H, whereas 5′-XMP di-Na salt [25899-70-1], 5′-AMP di-Na salt [4578-31-8], and 5′-CMP di-Na salt [6757-06-8] did not. None of these nucleotides affected the lower level of binding to the type II preparation Neither the free bases, adenine [73-24-5] and guanine [73-40-5], their nucleosides nor their di- or triphosphononucleotides were effective in increasing L-glutamate-³H binding to the type I preparation The nucleotide specificity of the glutamate binding enhancement therefore shows a marked similarity with the nucleotide specificity in evoking the synergistic taste effect in humans. Using 5′-GMP stimulation as a model, it appeared that the major effect was to increase the maximum binding of L-glutamate-³H, but no marked change in K_d was apparent. The 5′-ribonucleotide may act to increase the extent of L-glutamate binding by unmasking previously hidden or buried receptor sites for L-glutamate. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8COA of Formula: C9H12N3Na2O8P).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.COA of Formula: C9H12N3Na2O8P

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Insulin sensitizes beta-agonist and forskolin-stimulated lipolysis to inhibition by 2′,5′-dideoxyadenosine. was written by Gokmen-Polar, Y;Coronel, E C;Bahouth, S W;Fain, J N. And the article was included in The American journal of physiology in 1996.Electric Literature of C10H13N5O2 This article mentions the following:

In isolated rat adipocytes incubated in the absence of insulin, 2′,5′-dideoxyadenosine blocked the increase in total adenosine 3′,5′-cyclic monophosphate (cAMP) accumulation due to beta 1- or beta 3-catecholamine agonists and forskolin without affecting their stimulation of lipolysis. The inhibition of cAMP accumulation by 2′,5′-dideoxyadenosine was not reflected in the total cytosolic cAMP-dependent protein kinase A activity, suggesting that the inhibition of cAMP occurred in cellular compartments distinct from those involved in the regulation of bulk protein kinase A activity. However, there was a good correlation between effects of lipolytic agents on cytosolic protein kinase A activity in fat cell extracts and lipolysis. Furthermore, it was possible to see an inhibition of the increase due to beta-agonists in cAMP accumulation, protein kinase A activity, and lipolysis by 2′,5′-dideoxyadenosine in the presence of insulin. These data suggest that the readily measurable accumulation of cAMP seen with catecholamines in the absence of insulin is in a compartment separate from that involved in protein kinase A activation. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Electric Literature of C10H13N5O2).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C10H13N5O2

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Cordycepin induces apoptosis in human tongue cancer cells in vitro and has antitumor effects in vivo was written by Zheng, Qingwei;Sun, Jing;Li, Wenli;Li, Shuangnan;Zhang, Kai. And the article was included in Archives of Oral Biology in 2020.Application of 73-03-0 This article mentions the following:

This study was designed to explore the ability of cordycepin to disrupt human tongue cancer cell growth, and to assess the mechanistic basis for such anti-cancer activity. CAL-27 human tongue cancer cells were treated with cordycepin prior to anal. via CCK-8 assay in order to assess their proliferation. In addition, cell cycle progression and apoptotic death in these cells were measured via flow cytometry, while the expression of apoptosis-associated genes and proteins (caspase-3, caspase-9, caspase-12, Bcl-2, and Bax) were measured via real-time PCR and western blotting. Cordycepin was able to significantly suppress the proliferation of CAL-27 cells in a dose-dependent fashion (IC₅₀ = 40μg/mL at 24 h). Cordycepin further induced Bax, caspase-3, caspase-9, and caspase-12 upregulation at the mRNA and protein levels while simultaneously downregulating anti-apoptotic Bcl-2 expression. CAL-27 cells treated using cordycepin also exhibited elevated levels of intracellular ROS. Importantly, cordycepin was able to effectively suppress tongue cancer tumor growth in a murine xenograft model system and similar mRNA and protein levels were observed in vivo. Cordycepin can inhibit human tongue cancer cell growth and can drive their apoptotic death via the mitochondrial pathway. In addition, cordycepin can suppress tongue cancer growth in vivo in treated mice. In the experiment, the researchers used many compounds, for example, (2R,3R,5S)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol (cas: 73-03-0Application of 73-03-0).

(2R,3R,5S)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol (cas: 73-03-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Application of 73-03-0

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine was written by Niemann, Birte;Haufs-Brusberg, Saskia;Puetz, Laura;Feickert, Martin;Jaeckstein, Michelle Y.;Hoffmann, Anne;Zurkovic, Jelena;Heine, Markus;Trautmann, Eva-Maria;Mueller, Christa E.;Toenjes, Anke;Schlein, Christian;Jafari, Azin;Eltzschig, Holger K.;Gnad, Thorsten;Blueher, Matthias;Krahmer, Natalie;Kovacs, Peter;Heeren, Joerg;Pfeifer, Alexander. And the article was included in Nature (London, United Kingdom) in 2022.Safety of 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one This article mentions the following:

Brown adipose tissue (BAT) dissipates energy and promotes cardiometabolic health. Loss of BAT during obesity and ageing is a principal hurdle for BAT-centered obesity therapies, but not much is known about BAT apoptosis. Here, untargeted metabolomics demonstrated that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched. This apoptotic secretome enhances expression of the thermogenic program in healthy adipocytes. This effect is mediated by the purine inosine that stimulates energy expenditure in brown adipocytes by the cyclic adenosine monophosphate-protein kinase A signalling pathway. Treatment of mice with inosine increased BAT-dependent energy expenditure and induced ′browning′ of white adipose tissue. Mechanistically, the equilibrative nucleoside transporter 1 (ENT1, SLC29A1) regulates inosine levels in BAT: ENT1-deficiency increases extracellular inosine levels and consequently enhances thermogenic adipocyte differentiation. In mice, pharmacol. inhibition of ENT1 as well as global and adipose-specific ablation enhanced BAT activity and counteracted diet-induced obesity, resp. In human brown adipocytes, knockdown or blockade of ENT1 increased extracellular inosine, which enhanced thermogenic capacity. Conversely, high ENT1 levels correlated with lower expression of the thermogenic marker UCP1 in human adipose tissues. Finally, the Ile216Thr loss of function mutation in human ENT1 was associated with significantly lower body mass index and 59% lower odds of obesity for individuals carrying the Thr variant. Our data identify inosine as a metabolite released during apoptosis with a ′replace me′ signalling function that regulates thermogenic fat and counteracts obesity. In the experiment, the researchers used many compounds, for example, 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one (cas: 118-00-3Safety of 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one).

2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one (cas: 118-00-3) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fast atom bombardment tandem mass spectrometry in the identification of isomeric ribomononucleotides was written by Ghosh, D.;Newton, R. P.;Brenton, A. G.;Harris, F. M.;Donovan, M. P.;Brown, E. G.;Walton, T. J.. And the article was included in Analytica Chimica Acta in 1991.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate This article mentions the following:

Anal. of isomeric ribomononucleotides by pos.-ion fast atom bombardment tandem mass spectrometry is described. Daughter ion spectra generated by collision-induced dissociation-mass-analyzed ion kinetic energy scanning on a sector instrument are compared with daughter ion spectra from a triple quadrupole mass spectrometer, and criteria are established for the differentiation of th 2′,3′- and 5′-monophosphate isomers of adenosine, guanosine and cytosine, based on their characteristic fragmentation patterns. The value of tandem mass spectrometry in the identification of nucleotides extracted from biol. systems and isolated by HPLC and in the study of nucleotide metabolism is discussed. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate).

Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem