Month: February 2023

Role of regulator of G-protein signaling 2 (RGS2) in periodontal ligament cells under mechanical stress was written by Santos de Araujo, Rui M.;Oba, Yasuo;Moriyama, Keiji. And the article was included in Cell Biochemistry and Function in 2007.Related Products of 6698-26-6 This article mentions the following:

Mech. stress is thought to regulate the expression of genes in the periodontal ligament (PDL) cells. Using a microarray approach, we recently identified a regulator of G-protein signaling 2 (RGS2) as an up-regulated gene in the PDL cells under compressive force. The RGS protein family is known to turn off G-protein signaling. G-protein signaling involves the production of cAMP, which is thought to be one of the biol. mediators in response to mech. stress. Here, we investigated the role of RGS2 in the PDL cells under mech. stress. PDL cells derived from the ligament tissues of human premolar teeth were cultured in collagen gels and subjected to static compressive force. Compressive force application time-dependently enhanced RGS2 expression and intracellular cAMP levels. To examine the interrelationship between RGS2 and cAMP, the PDL cells were treated with 2′,5′-dideoxyadenosine (DDA), an inhibitor of adenyl cyclase, or antisense S-oligonucleotide (S-ODN) to RGS2 under compressive force. DDA dose-dependently inhibited RGS2 stimulated by compressive force. Blockage of RGS2 by antisense S-ODN elevated the cAMP levels compared with controls. These results indicate that cAMP stimulates RGS2 expression, which in turn leads to a decrease in the cAMP production by inactivating the G-protein signaling in the mech. stressed PDL cells. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Related Products of 6698-26-6).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Related Products of 6698-26-6

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Morphology-Controlled Self-Assembly and Synthesis of Biopolyimide Particles from 4-Amino-L-phenylalanine was written by Hirayama, Thawinda;Kumar, Amit;Takada, Kenji;Kaneko, Tatsuo. And the article was included in ACS Omega in 2020.COA of Formula: C13H12O6 This article mentions the following:

Self-assembling polyimides (PIs) having diketopiperazine (DKP) components were synthesized by polycondensation of a 4-amino-L-phenylalanine (4APhe) dimer, an aromatic diamine newly designed in this study. The amino acid-derived PIs showed high thermal resistance, with a 10% weight loss temperature (T_d10) of 432°C at the maximum, and did not show any glass transition below the thermal decomposition temperature The poly(amic acid) (PAA) precursors formed nanospheres upon reprecipitation over dimethylacetamide into water. The nanospheres were then added to solvents with different polarities and sonicated to induce deformation of the spherical forms into spiky balls, flakes, or rods. The PAA particle morphologies were retained in the PIs after the two-step imidization. Finally, the PI particles with self-assembling DKP moieties were formed, and their morphologies were fine-tuned using different mixed solvents. In the experiment, the researchers used many compounds, for example, 6-(2,5-Dioxotetrahydrofuran-3-yl)-4-methyl-7,7a-dihydroisobenzofuran-1,3(3aH,6H)-dione (cas: 73003-90-4COA of Formula: C13H12O6).

6-(2,5-Dioxotetrahydrofuran-3-yl)-4-methyl-7,7a-dihydroisobenzofuran-1,3(3aH,6H)-dione (cas: 73003-90-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.COA of Formula: C13H12O6

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Effects of leaf colorness, pigment contents and allelochemicals on the orientation of the Asian citrus psyllid among four Rutaceae host plants was written by Zhong, Zao-Fa;Zhou, Xiao-Juan;Lin, Jin-Bei;Liu, Xin-Jun;Shao, Jia;Zhong, Ba-Lian;Peng, Ting. And the article was included in BMC Plant Biology in 2019.Application In Synthesis of (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol hydrate This article mentions the following:

Background: Asian citrus psyllid (ACP) is the primary vector responsible for the transmission of the phloem-limited bacteria Candidatus Liberibacter spp., associated with huanglongbing (HLB), which causes great loss to the citrus industry. Although the roles of leaf color and volatile compounds in the orientation of ACP have been proven, the quantification of color and allelochems. in the host plant are kept unclear, especially in wild citrus germplasms. Results: Chongyi wild mandarin significantly attracted more ACP than wild Hong Kong kumquat, ‘Gannan zao’ navel orange and orange jasmine did in the four-choice and olfactometer assays. The color parameters of the tender leaves from Chongyi wild mandarin and ‘Gannan zao’ were similar. The yellow color in both of them was less saturated than that of the other two plants species, but Chongyi wild mandarin had significant lower carotenoid content (P < 0.05). Flavonoids accounted for a large group of secondary metabolites of interest, which may function as stimulants or repellents of ACP. This kind of synergistic or antagonistic effect among the metabolites differentially accumulated in Chongyi wild mandarin made it a more attractive host plant to ACP. Conclusions: Less saturated yellow color, high amount of attractants, low amount of repellents and insensitivity of JA-mediated wounding response are the four possible reasons why Chongyi wild mandarin attracted more ACP. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol hydrate (cas: 16373-93-6Application In Synthesis of (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol hydrate).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol hydrate (cas: 16373-93-6) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Application In Synthesis of (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol hydrate

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement was written by Que, Yunduan;Yang, Yuhang;Zafar, Hajra;Wang, Dongming. And the article was included in Frontiers in Pharmacology in 2022.Formula: C41H68O14 This article mentions the following:

We aimed to create a nano drug delivery system with tetracycline (TC)- grafted methoxy poly-(ethylene-glycol)-poly-(D, L-lactic-co-glycolic acid) (mPEG-PLGA) micelles (TC-mPEG-PLGA) with TC and mPEG-PLGA for potential bone targeting. Prospectively, TC-mPEG-PLGA aims to deliver bioactive compounds, such as astragaloside IV (AS), for osteoporotic therapy. Preparation and evaluation of TC-mPEG-PLGA were accomplished via nano-properties, cytotoxicity, uptake by MC3T3-E1 cells, ability of hydroxyapatite targeting and potential bone targeting in vivo, as well as pharmacodynamics in a rat model. The measured particle size of AS-loaded TC-mPEG-PLGA micelles was an average of 52.16 ± 2.44 nm, which exhibited a sustained release effect compared to that by free AS. The TC-mPEG-PLGA demonstrated low cytotoxicity and was easily taken by MC3T3-E1 cells. Through assaying of bone targeting in vitro and in vivo, we observed that TC-mPEG-PLGA could effectively increase AS accumulation in bone. A pharmacodynamics study in mice suggested potentially increased bone mineral d. by AS-loaded TC- mPEG-PLGA in ovariectomized rats compared to that by free AS. The nano drug delivery system (TC-mPEG-PLGA) could target bone in vitro and in vivo, wherein it may be used as a novel delivery method for the enhancement of therapeutic effects of drugs with osteoporotic activity. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 84687-43-4Formula: C41H68O14).

(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 84687-43-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Formula: C41H68O14

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new method of synthesis of fluorescently labeled oligonucleotides and their application in DNA sequencing was written by Markiewicz, Wojciech T.;Groger, Gabriele;Rosch, Rudi;Zebrowska, Anna;Markiewicz, Maria;Klotz, Margit;Hinz, Michael;Godzina, Przemyslaw;Seliger, Hartmut. And the article was included in Nucleic Acids Research in 1997.Safety of 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one This article mentions the following:

A new approach to the chem. synthesis of oligodeoxynucleotides bearing reporter functional groups at base residues of 3′-end nucleosides is reported. Applications of the 3′-end fluorescently labeled primers for automated DNA sequencing are shown. In the experiment, the researchers used many compounds, for example, 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 13389-03-2Safety of 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one).

2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 13389-03-2) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Safety of 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Transient conductivity of 1,3-dimethyluracil, uridine and 3-methyluridine in aqueous solution following 20-ns laser excitation at 248 nm was written by Goerner, Helmut;Currell, Leslie J.. And the article was included in Radiation Physics and Chemistry in 1996.Category: tetrahydrofurans This article mentions the following:

Uridine, 3-methyluridine and 1,3-dimethyluracil in aqueous solution were studied by time-resolved conductimetry after excitation at 248 nm by 20-ns laser pulses. The conductivity signal increases to the maximum value at the pulse end (Δκ^m) and decreases then with time, depending on the saturating gas (Ar, N₂O, O₂ or MeCl) and pH. The Δκ^m signal is suggested to originate from hydrated electrons (e_aq^–) and protons, the latter resulting from radical cations after rapid reaction with water. Biphotonic photoionization occurs in the whole pH range 3-11 with a quantum yield of 0.016 or smaller for laser intensities of ≤8 MW/cm². The reaction of e_aq^– with uncharged bases in Ar-saturated solution at pH 5-8 generates radical anions which are subsequently protonated. The neutralization reaction kinetics of the uracil derivatives depend essentially on the transient proton concentration and lead to the disappearance of most of the conductivity (>90%) within a few microseconds or less in neutral or acidic solution, resp. For 3-methyluridine and uridine after neutralization, the presence of a long-lived species with acidic properties was observed (in small yield) upon biphotonic (but not monophotonic) excitation. The time-resolved conductivity pattern in the alk. pH range is different for each of the three pyrimidines, depending essentially on the generation or consumption of OH^– in the radical termination reactions. In the experiment, the researchers used many compounds, for example, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methylpyrimidine-2,4(1H,3H)-dione (cas: 2140-69-4Category: tetrahydrofurans).

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methylpyrimidine-2,4(1H,3H)-dione (cas: 2140-69-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Determination of p-acetaminobenzoic acid and N,N-dimethylamino-2-propanol in human urine by LC-MS and study on their urinary excretion profiles was written by Yu, Yong;Sun, Luning;Du, Xiaolang;Rao, Yakun;Ding, Wen;Ding, Li;Xiao, Huifeng;Chen, Yizhi. And the article was included in Yaoxue Jinzhan in 2011.Synthetic Route of C52H78N10O17 This article mentions the following:

LC-MS methods were established for the sep. determination of p-acetaminobenzoic acid (PAcBA) and N,N-dimethylamino-2-propanol (DIP) in human urine, and their urinary excretion profiles in Chinese healthy volunteers were investigated. PAcBA in urine was determined by LC-MS using Amethyst C₁₈-P column, with methanol-0.1% formic acid (25:75) as the mobile phase at a flow rate of 0.4 mL/min^-1 and pos. ion SIM detection; DIP in urine was determined by LC-MS/MS using Hedera CN column, with acetonitrile-5 mmol/L^-1 ammonium acetate (55:45) containing 0.03% formic acid as the mobile phase at a flow rate of 0.35 mL/min^-1 and pos. ion MRM detection. The urinary excretion parameters of PAcBA and DIP were measured after a single oral administration of isoprinosine tablets (1.0 g) in 10 volunteers. The calibration curve was linear in the range of 0.2020-202.0 mg/L^-1 for PAcBA in urine or in the range of 0.7978-398.9 mg/L^-1 for DIP in urine. The average recoveries of PAcBA and DIP in urine were more than 97.7% and 99.1%, resp. After taking the tablets, PAcBA and DIP were almost completely excreted in urine and the average cumulative excretion percentages of PAcBA and DIP in urine within 36 h were (30.7±5.7)% and (49.0±8.6)%, resp. The methods were suitable for the determination of PAcBA and DIP in human urine and for the investigation on their urinary excretion profiles. In the experiment, the researchers used many compounds, for example, 4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3) (cas: 36703-88-5Synthetic Route of C52H78N10O17).

4-Acetamidobenzoic acid,9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one,1-(Dimethylamino)propan-2-ol (3:1:3) (cas: 36703-88-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Synthetic Route of C52H78N10O17

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Optimum Induction of Recombinant Thymidine Phosphorylase and Its Application was written by Ding, Qingbao;Ou, Ling;Wei, Dongzhi;Wei, Xiaokun. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2011.SDS of cas: 10356-76-0 This article mentions the following:

Recombinant E. coli pDEOA was constructed and lactose can be used instead of IPTG to induce the expression of thymidine phosphorylase by pDEOA. The use of lactose at concentrations higher than 0.5 mmol/L had an induction effect similar to that of IPTG but resulted in a longer initial induction time and better cell growth. The thymidine phosphorylase induced by lactose was very stable at 50°C. Intact pDEOA cells induced by lactose can be used as a source of thymidine phosphorylase. Under standard reaction conditions, several deoxynucleosides were effectively produced from thymidine. In the experiment, the researchers used many compounds, for example, 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0SDS of cas: 10356-76-0).

4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.SDS of cas: 10356-76-0

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Evidence for a long-term influence on morphine tolerance after previous morphine exposure: role of neuronal glucocorticoid receptors was written by Lim, Grewo;Wang, Shuxing;Zeng, Qing;Sung, Backil;Mao, Jianren. And the article was included in Pain in 2005.Application of 6698-26-6 This article mentions the following:

Opioid analgesic tolerance is a pharmacol. phenomenon that overtime diminishes the opioid analgesic effect. However, it remains unknown as to whether a previous opioid exposure would have a long-term influence on opioid tolerance upon subsequent opioid administration. Here, we show that the onset and degree of antinociceptive tolerance to a subsequent cycle of morphine exposure were substantially exacerbated in rats made tolerant to and then recovered from previous morphine administration, indicating a long-term influence from a previous morphine exposure on the development of morphine tolerance. Mechanistically, morphine exposure induced a cAMP and protein kinase A-dependent upregulation of neuronal glucocorticoid receptors (GR) within the spinal cord dorsal horn, which was maintained after discontinuation of morphine administration and significantly enhanced upon a second cycle of morphine exposure. Prevention of the GR upregulation with GR antisense oligonucleotides as well as inhibition of GR activation with the GR antagonist RU38486 effectively prevented the exacerbated morphine tolerance after subsequent cycles of morphine exposure. The results indicate that a previous morphine exposure could induce lasting cellular changes mediated through neuronal GR and influence morphine analgesia upon a subsequent exposure. These findings may have significant implications in clin. opioid therapy and substance abuse. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6Application of 6698-26-6).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Application of 6698-26-6

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fluorescent Probes for Ecto-5′-nucleotidase (CD73) was written by Schmies, Constanze C.;Rolshoven, Georg;Idris, Riham M.;Losenkova, Karolina;Renn, Christian;Schaekel, Laura;Al-Hroub, Haneen;Wang, Yulu;Garofano, Francesca;Schmidt-Wolf, Ingo G. H.;Zimmermann, Herbert;Yegutkin, Gennady G.;Mueller, Christa E.. And the article was included in ACS Medicinal Chemistry Letters in 2020.Reference of 3056-18-6 This article mentions the following:

Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an immunosuppressive microenvironment. In the present study we designed and synthesized fluorescent-labeled CD73 inhibitors with low nanomolar affinity and high selectivity based on N⁶-benzyl-α,β-methylene-ADP (PSB-12379) as a lead structure. Fluorescein was attached to the benzyl residue via different linkers resulting in PSB-19416 (14b, K_i 12.6 nM) and PSB-18332 (14a, K_i 2.98 nM) as fluorescent high-affinity probes for CD73. These compounds are anticipated to become useful tools for biol. studies, drug screening, and diagnostic applications. In the experiment, the researchers used many compounds, for example, (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate (cas: 3056-18-6Reference of 3056-18-6).

(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate (cas: 3056-18-6) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Reference of 3056-18-6

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem