Month: February 2023

Synthesis of 5-fluoro-4-deoxy-β-L-uridine was written by Dong, Chun-Hong;Qi, Xiu-Xiang;Yu, Xue-Jun;Chang, Jun-Biao. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2004.Category: tetrahydrofurans This article mentions the following:

The title compound was prepared in 10 steps starting from L-xylose via condensation of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose with silylated 5-fluorouracil. The structures of compounds were identified by the MS, UV, IR, ¹H NMR spectra and elemental analyses. In the experiment, the researchers used many compounds, for example, (3aS,5S,6R,6aS)-5-(Hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (cas: 114861-22-2Category: tetrahydrofurans).

(3aS,5S,6R,6aS)-5-(Hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (cas: 114861-22-2) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ammonium ions enhance proteolytic activation of adenylate cyclase and decrease its sensitivity to inhibition by “P”-site agonists was written by Yeung, Siu Mei Helena;Shoshani, Ilana;Stuebner, Dorothee;Johnson, Roger A.. And the article was included in Archives of Biochemistry and Biophysics in 1989.COA of Formula: C10H13N5O2 This article mentions the following:

A detergent-dispersed adenylate cyclase from rat brain was used to study the effects of ammonium salts and polyamines on the proteolytic activation of the enzyme by a sperm protease and on the sensitivity of adenylate cyclase to inhibition via its P-site. A purified preparation of a trypsinlike serine protease from bovine sperm was used to activate solubilized adenylate cyclase in the presence of guanosine 5′-O-(3-thiotriphosphate (GTPγS). The proteolytically activated form of adenylate cyclase was particularly sensitive to further activation by NH₄HCO₃. The activation by NH₄HCO₃ was due to the NH₄⁺ cation and was characterized by an increased V_max and by a decreased sensitivity of adenylate cyclase to inactivation by elevated concentrations of the sperm protease or by trypsin. NH₄Cl and (NH₄)₂SO₄ also caused biphasic effects on adenylate cyclase, that mimicked but were less effective than those caused by NH₄HCO₃. Consistent with observations of others, adenylate cyclase activity was enhanced by NH⁺ whether in the presence of reversible (Mn²⁺) or irreversible (GTPγS) activators. Mn²⁺– and GTPγS-stimulated activities were similarly optimally enhanced by 30 mM (NH₄)₂SO₄ and by 30-150 mM NH₄Cl or NH₄HCO₃. NH₄⁺ did not increase the activity of the purified catalytic unit. Moreover, the effect of NH₄⁺ was not accompanied by an increased rate of activation by GTPγS, suggesting that the activation of G_s (guanine nucleotide-dependent stimulatory component) may not be the primary cause of stimulation by ammonium salts. Several polyamines at millimolar concentrations blocked the stimulatory effect of NH₄⁺. This was observed when adenylate cyclase was activated by Mn²⁺, but not when it was activated by GTPγS or by the sperm protease plus GTPγS. The inhibitory effect of polyamines was not due to the formation of a complex with ATP. Both the increase in V_max of the Mn²⁺-stimulated enzyme by NH₄⁺ and the decrease in V_max caused by spermine were accompanied by an increase in the apparent K_m for MnATP. Spermine increased the IC₅₀ for inhibition of Mn²⁺-activated adenylate cyclase by 2′,5′-dideoxyadenosine (2′,5′-ddAdo) from 0.75 to 4.6 μM, consistent with the idea that increased sensitivity of P-site-mediated inhibition is associated with increased enzyme activity. In contrast, activation of Mn²⁺-stimulated adenylate cyclase by 30 mM (NH₄)₂SO₄ also reduced sensitivity to inhibition by 2′,5′-ddAdo (IC₅₀ 1.1 μM). This decreased sensitivity to inhibition by 2′,5′-ddAdo induced by NH₄⁺ was also observed on GTPS-activated or proteolytically activated adenylate cyclase. Thus, activation of adenylate cyclase by ammonium salts may be due to an effect on the conformation and(or) stability of the active form of the enzyme, leading to increased enzyme activity as well as to decreased proteolytic inactivation. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6COA of Formula: C10H13N5O2).

(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-methyltetrahydrofuran-3-ol (cas: 6698-26-6) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.COA of Formula: C10H13N5O2

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sensitive high-throughput assays for tumour burden reveal the response of a Drosophila melanogaster model of colorectal cancer to standard chemotherapies was written by Adams, Jamie;Casali, Andreu;Campbell, Kyra. And the article was included in International Journal of Molecular Sciences in 2021.Related Products of 3094-09-5 This article mentions the following:

Drosophila melanogaster (Drosophila) models of cancer are emerging as powerful tools to investigate the basic mechanisms underlying tumor progression and identify novel therapeutics. Rapid and inexpensive, it is possible to carry out genetic and drug screens at a far larger scale than in vertebrate organisms. Such whole-organism-based drug screens permits assessment of drug absorption and toxicity, reducing the possibility of false positives. Activating mutations in the Wnt and Ras signalling pathways are common in many epithelial cancers, and when driven in the adult Drosophila midgut, it induces aggressive intestinal tumor-like outgrowths that recapitulate many aspects of human colorectal cancer (CRC). Here we have taken a Drosophila CRC model in which tumorous cells are marked with both GFP and luciferase reporter genes, and developed novel high-throughput assays for quantifying tumor burden. Leveraging these assays, we find that the Drosophila CRC model responds rapidly to treatment with standard CRC-drugs, opening the door to future rapid genetic and drug screens. In the experiment, the researchers used many compounds, for example, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5Related Products of 3094-09-5).

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Related Products of 3094-09-5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nucleic Acid Related Compounds. 118. Nonaqueous Diazotization of Aminopurine Derivatives. Convenient Access to 6-Halo- and 2,6-Dihalopurine Nucleosides and 2′-Deoxynucleosides with Acyl or Silyl Halides was written by Francom, Paula;Robins, Morris J.. And the article was included in Journal of Organic Chemistry in 2003.Category: tetrahydrofurans This article mentions the following:

Treatment of 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-amino-6-chloropurine with TMS-Cl and benzyltriethylammonium nitrite (BTEA-NO₂) in dichloromethane gave the crystalline 2,6-dichloropurine nucleoside I (R = OAc, X = Y = Cl), and acetyl chloride/BTEA-NO₂ was equally effective (∼85%, without chromatog.). TMS-Br/tert-Bu nitrite/dibromomethane gave crystalline 2-bromo-6-chloro analog I (R = OAc, X = Br, Y = Cl) (85%). (Chloro or bromo)-dediazoniation of 3′,5′-di-O-acetyl-2′-deoxyadenosine gave chloro I (R = X = H, Y = Cl) (63%) or bromo I (R = X = H, Y = Br) (80%) purine deoxynucleosides, and 2′,3′,5′-tri-O-acetyladenosine was converted into the 6-chloropurine nucleoside I (R = OAc, X = H, Y = Cl) (71%). In the experiment, the researchers used many compounds, for example, (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate (cas: 3056-18-6Category: tetrahydrofurans).

(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate (cas: 3056-18-6) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spectrofluorimetric method for the determination of alfuzosin and flavoxate hydrochlorides in pharmaceuticals and biological fluids was written by Razeq, Sawsan A.. And the article was included in Egyptian Journal of Analytical Chemistry in 2008.Electric Literature of C19H28ClN5O4 This article mentions the following:

A simple and sensitive spectrofluorimetric method was developed to determine alfuzosin-HCl and flavoxate-HCl. Maximum fluorescence intensity was achieved in pure water at 388 nm and 375 nm using λex 244 nm and 240 nm for alfuzosin-HCl and flavoxate-HCl, resp. The optimum exptl. parameters such as solvent, micelle-enhancement, and pH were evaluated. Good correlations were obtained between the fluorescence intensity and concentration in the ranges of 2.5-30 ng/mL for alfuzosin and 1-6 μg/mL for flavoxate-HCl. The suggested method was successfully applied to estimate the 2 drugs in their tablets with average recoveries of 99.2 and 99.8%, resp. These results were found to agree with those of reference methods. The method also retained its accuracy and precision when applied to determine alfuzosin-HCl in spiked blood serum or urine as judged by an average recovery of 95.4 or 100.1%, resp. Furthermore, the method was validated according to the International Conference on Harmonization. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Electric Literature of C19H28ClN5O4).

N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Electric Literature of C19H28ClN5O4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Feedback inhibition of asparate transcarbamylase in liver and in hepatoma was written by Bresnick, Edward. And the article was included in Cancer Research in 1962.SDS of cas: 10356-76-0 This article mentions the following:

Partially purified asparate transcarbamylase (I) from rat liver, Morris hepatoma 5123-A or D, Hepatoma 7800, and Novikoff hepatoma, was shown to be inhibited by pyrimidine deoxyribonucleosides and deoxyribonucleotides. The pyrimidine analogs, 5-bromo-2′-deoxyuridine, 5-bromouridine, 5-bromo-2′-deoxycytidine, 5-fluoro-2′-deoxyuridine, 5-fluorouridine, 5-fluoro-2′-deoxycytidine, 5-iodo-2-deoxyuridine, also inhibited enzymic activity. The most effective inhibitors were 2′-deoxyadenosine 5′-monophosphate (or 2′-deoxyguanosine 5′-monophosphate) and 2′-deoxyadenosine (II) or 2′-deoxyguanosine (III). I was identical in liver and in the hepatomas by pH optimum, K_m values for carbamoyl phosphate and asparate, V_maximum degree of inhibition by Cu⁺⁺, by the pyrimidines, and by the inhibition constants Neg. feedback inhibition of pyrimidine biosynthesis occurs in hepatomas as well as in liver, and to the same extent. Furthermore, the control of I by II (or III) may play a significant role in vivo. In the experiment, the researchers used many compounds, for example, 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0SDS of cas: 10356-76-0).

4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.SDS of cas: 10356-76-0

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Decarboxylative C-C and C-N Bond Formation by Ligand-Accelerated Iron Photocatalysis was written by Feng, Guangshou;Wang, Xiaofei;Jin, Jian. And the article was included in European Journal of Organic Chemistry in 2019.Electric Literature of C5H8O3 This article mentions the following:

A mild and effective protocol for decarboxylative C-C and C-N bond formation through iron photocatalysis was achieved. The carboxylic acids underwent radical decarboxylation in the presence of Fe₂(SO₄)₃ and di-(2-picolyl)amine under visible light irradiation The resulting alkyl radicals then reacted with Michael acceptors or azodicarboxylates to furnish the adducts. In the experiment, the researchers used many compounds, for example, Tetrahydrofuran-2-carboxylic acid (cas: 16874-33-2Electric Literature of C5H8O3).

Tetrahydrofuran-2-carboxylic acid (cas: 16874-33-2) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Electric Literature of C5H8O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

HIV pre-exposure prophylaxis for women and infants prevents vaginal and oral HIV transmission in a preclinical model of HIV infection was written by Kovarova, Martina;Shanmugasundaram, Uma;Baker, Caroline E.;Spagnuolo, Rae Ann;De, Chandrav;Nixon, Christopher C.;Wahl, Angela;Garcia, J. Victor. And the article was included in Journal of Antimicrobial Chemotherapy in 2016.Electric Literature of C12H12FN5O3 This article mentions the following:

Background: Approx. 1.5 million HIV-pos. women become pregnant annually. Without treatment, up to 45% will transmit HIV to their infants, primarily through breastfeeding. These numbers highlight that HIV acquisition is a major health concern for women and children globally. They also emphasize the urgent need for novel approaches to prevent HIV acquisition that are safe, effective and convenient to use by women and children in places where they are most needed. Methods: 4′-Ethynyl-2-fluoro-2′-deoxyadenosine, a potent NRTI with low cytotoxicity, was administered orally to NOD/SCID/γc/ mice and to bone marrow/liver/thymus (BLT) humanized mice, a preclin. model of HIV infection. HIV inhibitory activity in serum, cervicovaginal secretions and saliva was evaluated 4 h after administration. 4′-Ethynyl-2-fluoro-2′-deoxyadenosine’s ability to prevent vaginal and oral HIV transmission was evaluated using highly relevant transmitted/founder viruses in BLT mice. Results: Strong HIV inhibitory activity in serum, cervicovaginal secretions and saliva obtained from animals after a single oral dose of 4′-ethynyl-2-fluoro-2′-deoxyadenosine (10 mg/kg) demonstrated efficient drug penetration into relevant mucosal sites. A single daily oral dose of 4′-ethynyl-2-fluoro-2′-deoxyadenosine resulted in efficient prevention of vaginal and oral HIV transmission after multiple high-dose exposures to transmitted/founder viruses in BLT humanized mice. Conclusions: Our data demonstrated that 4′-ethynyl-2-fluoro-2′-deoxyadenosine efficiently prevents both vaginal and oral HIV transmission. Together with 4′-ethynyl-2-fluoro-2′-deoxyadenosine’s relatively low toxicity and high potency against drug-resistant HIV strains, these data support further clin. development of 4′-ethynyl-2-fluoro-2′-deoxyadenosine as a potential pre-exposure prophylaxis agent to prevent HIV transmission in women and their infants. In the experiment, the researchers used many compounds, for example, (2R,3S,5R)-5-(6-Amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol (cas: 865363-93-5Electric Literature of C12H12FN5O3).

(2R,3S,5R)-5-(6-Amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol (cas: 865363-93-5) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Electric Literature of C12H12FN5O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Thin-layer chromatography of fluoropyrimidines was written by Hawrylyshyn, M.;Seniowski, B. Z.;Wollish, E. G.. And the article was included in Microchemical Journal in 1964.Safety of 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one This article mentions the following:

On plates coated with Silica Gel GF, with a 2-dimensional system using EtOAc-acetone-water (70:40:10) and EtOAc-MeOH-NH₄OH (75:25:1), a synthetic mixture of 10 compounds was separated R_f values are given for 5-fluoroorotic acid monohydrate, 5-fluorocytosine, 5-fluoro-2′-deoxycytidine, uracil, thymidine, 5-fluorouridine, thymine, 5-fluoro-2′-deoxyuridine, 5-fluorouraeil, and 5 fluoro-2′-deoxy-3′,5′ -diacetyluridine. In the experiment, the researchers used many compounds, for example, 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0Safety of 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).

4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway was written by Li, Fagen;Cao, Ke;Wang, Maoyun;Liu, Yi;Zhang, Yin. And the article was included in Bioengineered in 2022.Electric Literature of C41H68O14 This article mentions the following:

Astragaloside IV (AS-IV) is an inartificial saponin separated from astragalus membranaceus, which has exhibited key anti-tumor regulation in some cancers. Circular RNAs (circRNAs) are important regulators in malignant development of gastric cancer (GC). Herein, we focused on the mol. mechanism of AS-IV with circRNA dihydrolipoamide S-succinyltransferase (circDLST) in GC. CircDLST, microRNA-489-3p (miR-489-3p), and eukaryotic translation initiation factor 4A1 (EIF4A1) levels were detected by quant. real-time polymerase-chain reaction and western blot. Cell functions were assessed by cell counting kit-8 assay, ethynyl-2-deoxyuridine assay, colony formation assay, and transwell assay. The interaction between miR-489-3p and circDLST or EIF4A1 was analyzed by dual-luciferase reporter assay. Xenograft tumor assay was adopted to check the role of circDLST and AS-IV in vivo. CircDLST and EIF4A1 were upregulated but miR-489-3p was downregulated in GC cells. AS-IV restrained cell proliferation and metastasis in GC cells by downregulating circDLST. CircDLST served as a miR-489-3p sponge, and miR-489-3p inhibition reversed anti-tumor function of AS-IV. EIF4A1 was a target for miR-489-3p and circDLST sponged miR-489-3p to regulate EIF4A1. AS-IV suppressed GC cell progression via circDLST-mediated downregulation of EIF4A1. Also, AS-IV recued tumor growth in vivo via targeting circDLST to regulate miR-489-3p/EIF4A1 axis. AS-IV inhibited the development of GC through circDLST/miR-489-3p/EIF4A1 axis. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 84687-43-4Electric Literature of C41H68O14).

(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 84687-43-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Electric Literature of C41H68O14

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem