Normal and modified nucleosides in urine as potential tumor markers determined by MEKC and HPLC was written by Xu, Guowang;Liebich, Hartmut. And the article was included in American Clinical Laboratory in 2001.COA of Formula: C10H14N2O6 This article mentions the following:
A study was conducted which give further credence to previous observations that patterns of urinary excretion of modified nucleosides may serve as a useful diagnostic tool for malignant disease, especially when the pattern recognition method is used together with micellar electrokinetic capillary chromatog. or high-performance liquid chromatog. (HPLC). A major advantage for using the nucleosides as possible biomarkers lies in the MEKC or HPLC method. All of them can be accurately and quickly measured per individual urine and/or serum sample in one MEKC or HPLC run. Although further studies are needed, the use of modified nucleosides in combination with other biomarkers may have potential application as an adjunct to the clin. assessment of cancer patients. In the experiment, the researchers used many compounds, for example, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methylpyrimidine-2,4(1H,3H)-dione (cas: 2140-69-4COA of Formula: C10H14N2O6).
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methylpyrimidine-2,4(1H,3H)-dione (cas: 2140-69-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.COA of Formula: C10H14N2O6
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem