A proposal for a specific double-helical structure in which the polynucleotide strands intercalate instead of forming base-pairs was written by Viswamitra, M. A.;Pandit, J.. And the article was included in Journal of Biomolecular Structure & Dynamics in 1983.Category: tetrahydrofurans This article mentions the following:
A double-stranded helical DNA structure without any base pairs, but having a repeat unit of 2 nucleotides with their bases stacked through intercalation, is proposed. The proposal comes from the initial models built for poly(dC) by using the stacking patterns found in the crystal structures of 5′-dCMP-Na2 which crystallizes in 2 forms depending on the degree of hydration. These structures have pairs of nucleotides with the cytosine rings partially overlapping and separated by 3.3 Å. By using these as repeat units, one could generate a model for poly(dC) with parallel strands, having a turn angle of 30° and a base separation of 6.6 Å along each strand. Both right- and left-handed models with these parameters can be built in a smooth fashion without any obviously unreasonable stereochem. contacts. The helix diameter is ∼13.5 Å, much smaller than that of normal helixes with base-pair repeats. The changes in the sugar-phosphate backbone conformation in the present models compared to normal duplexes only reflect the torsional flexibility available for extension of polynucleotide chains as manifested by the crystal structures of drug-inserted oligonucleotide complexes. Intercalation proposed here could have some structural relevance elsewhere, e.g. to the base-mismatched regions on the double helix and the packing of noncomplementary single strands in the filamentous bacteriophage Pf1. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Category: tetrahydrofurans).
Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Category: tetrahydrofurans
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem