19 F MRSI of capecitabine in the liver at 7 T using broadband transmit-receive antennas and dual-band RF pulses was written by van Gorp, Jetse S.;Seevinck, Peter R.;Andreychenko, Anna;Raaijmakers, Alexander J. E.;Luijten, Peter R.;Viergever, Max A.;Koopman, Miriam;Boer, Vincent O.;Klomp, Dennis W. J.. And the article was included in NMR in Biomedicine in 2015.Reference of 3094-09-5 This article mentions the following:
Capecitabine (Cap) is an often prescribed chemotherapeutic agent, successfully used to cure some patients from cancer or reduce tumor burden for palliative care. However, the efficacy of the drug is limited, it is not known in advance who will respond to the drug and it can come with severe toxicity. 19 F Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Spectroscopic Imaging (MRSI) have been used to non-invasively study Cap metabolism in vivo to find a marker for personalized treatment. In vivo detection, however, is hampered by low concentrations and the use of radiofrequency (RF) surface coils limiting spatial coverage. In this work, the use of a 7T MR system with radiative multi-channel transmit-receive antennas was investigated with the aim of maximizing the sensitivity and spatial coverage of 19 F detection protocols. The antennas were broadband optimized to facilitate both the 1H (298 MHz) and 19 F (280 MHz) frequencies for accurate shimming, imaging and signal combination. B1+ simulations, phantom and noise measurements showed that more than 90% of the theor. maximum sensitivity could be obtained when using B1+ and B1– information provided at the 1H frequency for the optimization of B1+ and B1– at the 19 F frequency. Furthermore, to overcome the limits in maximum available RF power, while ensuring simultaneous excitation of all detectable conversion products of Cap, a dual-band RF pulse was designed and evaluated. Finally, 19 F MRS(I) measurements were performed to detect 19 F metabolites in vitro and in vivo. In two patients, at 10 h (patient 1) and 1 h (patient 2) after Cap intake, 19 F metabolites were detected in the liver and the surrounding organs, illustrating the potential of the set-up for in vivo detection of metabolic rates and drug distribution in the body. Copyright © 2015 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5Reference of 3094-09-5).
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione (cas: 3094-09-5) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Reference of 3094-09-5
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem