Spectrofluorimetric method for the determination of alfuzosin and flavoxate hydrochlorides in pharmaceuticals and biological fluids was written by Razeq, Sawsan A.. And the article was included in Egyptian Journal of Analytical Chemistry in 2008.Electric Literature of C19H28ClN5O4 This article mentions the following:
A simple and sensitive spectrofluorimetric method was developed to determine alfuzosin-HCl and flavoxate-HCl. Maximum fluorescence intensity was achieved in pure water at 388 nm and 375 nm using λex 244 nm and 240 nm for alfuzosin-HCl and flavoxate-HCl, resp. The optimum exptl. parameters such as solvent, micelle-enhancement, and pH were evaluated. Good correlations were obtained between the fluorescence intensity and concentration in the ranges of 2.5-30 ng/mL for alfuzosin and 1-6 μg/mL for flavoxate-HCl. The suggested method was successfully applied to estimate the 2 drugs in their tablets with average recoveries of 99.2 and 99.8%, resp. These results were found to agree with those of reference methods. The method also retained its accuracy and precision when applied to determine alfuzosin-HCl in spiked blood serum or urine as judged by an average recovery of 95.4 or 100.1%, resp. Furthermore, the method was validated according to the International Conference on Harmonization. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Electric Literature of C19H28ClN5O4).
N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Electric Literature of C19H28ClN5O4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem