Development and validation of new RP-HPLC method for the estimation of alfuzosin hydrochloride in bulk and tablet dosage form was written by Patil, Vandana P.;Devdhe, Subhash J.;Kale, Suwarna H.;Nagmoti, Vijay J.;Kurhade, Sadanand D.;Girbane, Yuvraj R.;Gaikwad, Mahesh T.. And the article was included in American Journal of Analytical Chemistry in 2013.Application In Synthesis of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride This article mentions the following:
A reverse phase high performance liquid chromatog. method HPLC has been developed for the estimation of Alfuzosin hydrochloride ALH in the pharmaceutical formulation using RP-C18 column. The mobile phase Tetrahy-drofuran, Acetonitrile and buffer pH 3.50 was pumped at a flow rate of 1.5 mL/min in the ratio of 1:20:80 and the eluents were monitored at 254.0 nm. Linearity was obtained in the concentration range of 80 – 120 μg/mL for ALH. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and preci-sion of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determination of Alfuzosin hydrochloride in bulk drugs and in pharmaceutical dosage form. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Application In Synthesis of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride).
N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Application In Synthesis of N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem