Development and characterization of pH-sensitive pectin/acrylic acid hydrogels for colon specific drug delivery was written by Javaid, Zeeshan;ul Rahman, Nisar;Ranjha, Nazar M.;Razzaq, Abida;Ali, Liaqat;Ahmad, Jawad. And the article was included in Latin American Journal of Pharmacy in 2012.Category: tetrahydrofurans This article mentions the following:
The present work was aimed to rationally design and synthesizes pH-sensitive crosslinked pectin/acrylic acid hydrogels for studying release pattern of alfuzosin HCl. Such hydrogels were prepared through free radical polymerizations Then these materials were used as model systems to envisage various important characterizations like Fourier Transform IR Spectroscopy (FTIR), X-ray Diffraction (X-RD), SEM (SEM) and thermal anal. In vitro release pattern of alfuzosin HCl was investigated in buffer solutions of pH 12, 5.5 and 7.5. The release kinetics was evaluated by applying zero order, first order, Higuchi and Peppas kinetic models. Dynamic and equilibrium swelling anal. was performed to predict release behavior and releasing site. Remarkable swelling was observed at higher pH values. FTIR spectra showed intensity of esterified carboxyl group at 1755.92 cm-1, which is of pure pectin, shifted to lower frequency indicating interaction between pectin and acrylic acid. Thermo gravimetric anal. indicated increase in thermal stability while Differential Scanning Calorimetry (DSC) results showed increase in enthalpy after copolymerization The release of drug followed zero order and exhibited non-fickian diffusion mechanism. As maximum of the drug released at pH 7.5, it depicts the character of this developed polymer as a suitable candidate for colon specific drug delivery. In the experiment, the researchers used many compounds, for example, N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1Category: tetrahydrofurans).
N-(3-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide hydrochloride (cas: 81403-68-1) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem