Thin-layer chromatography of fluoropyrimidines was written by Hawrylyshyn, M.;Seniowski, B. Z.;Wollish, E. G.. And the article was included in Microchemical Journal in 1964.Safety of 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one This article mentions the following:
On plates coated with Silica Gel GF, with a 2-dimensional system using EtOAc-acetone-water (70:40:10) and EtOAc-MeOH-NH4OH (75:25:1), a synthetic mixture of 10 compounds was separated Rf values are given for 5-fluoroorotic acid monohydrate, 5-fluorocytosine, 5-fluoro-2′-deoxycytidine, uracil, thymidine, 5-fluorouridine, thymine, 5-fluoro-2′-deoxyuridine, 5-fluorouraeil, and 5 fluoro-2′-deoxy-3′,5′ -diacetyluridine. In the experiment, the researchers used many compounds, for example, 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0Safety of 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).
4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem