Water-Soluble Pd-Imidate Complexes: Broadly Applicable Catalysts for the Synthesis of Chemically Modified Nucleosides via Pd-Catalyzed Cross-Coupling was written by Gayakhe, Vijay;Ardhapure, Ajaykumar;Kapdi, Anant R.;Sanghvi, Yogesh S.;Serrano, Jose Luis;Garcia, Luis;Perez, Jose;Garcia, Joaquim;Sanchez, Gregorio;Fischer, Christian;Schulzke, Carola. And the article was included in Journal of Organic Chemistry in 2016.Synthetic Route of C10H12BrN5O4 This article mentions the following:
A broadly applicable catalyst system consisting of water-soluble Pd-imidate complexes has been employed for the Suzuki-Miyaura cross-coupling of four different nucleosides in water under mild conditions. The efficient nature of the catalyst system also allowed its application in developing a microwave-assisted protocol with the purpose of expediting the catalytic reaction. Preliminary mechanistic studies, assisted by catalyst poison tests and stoichiometric tests performed using an electrospray ionization spectrometer, revealed the possible presence of a homotopic catalyst system. In the experiment, the researchers used many compounds, for example, 2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 13389-03-2Synthetic Route of C10H12BrN5O4).
2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 13389-03-2) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Synthetic Route of C10H12BrN5O4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem