A urinary metabonomics study on biochemical changes in yeast-induced pyrexia rats: A new approach to elucidating the biochemical basis of the febrile response was written by Gao, Xiaoyan;Guo, Mingxing;Zhao, Baosheng;Peng, Long;Su, Jiankun;Bai, Xu;Li, Jun;Qiao, Yanjiang. And the article was included in Chemico-Biological Interactions in 2013.Computed Properties of C10H14N2O6 This article mentions the following:
Fever is a prominent feature of many diseases, such as infection, inflammation and trauma. In the clinic, fever can be easily judged by measuring the body temperature; however, the pathogenesis of fever is still not fully understood. A febrile response is a systemic pathol. process that can cause metabolic disorders. Metabonomics can provide powerful tools to reveal the pathol. mechanisms for such a systemic disease. Thus, to reveal subtle metabolic changes under the condition of fever and to explore its mechanism, an ultra performance liquid chromatog. coupled with a quadrupole time-of-flight mass spectrometry metabonomics approach was employed to investigate the urine biochem. characteristics of yeast-induced pyrexia rats. The acquired data were subjected to principal component anal. for differentiating the pyrexia rats from the control rats. Potential biomarkers were screened by using orthogonal partial least-squares-discriminant anal. and were identified by accurate mass, database, and MS/MS fragment information obtained from the MSE technique. Sixteen metabolites in rat urine were identified as potential biomarkers. The relative intensities of the 15 potential biomarkers were calculated The thermoregulatory circuitry of “endogenous pyrogen (EP) ↑-hypothalamus Na+/Ca2+-cAMP↑” was partially confirmed in this study. The results suggested that UPLC/MS-based metabolic profiling of rat urine identifies impaired tryptophan metabolism as the mechanism of yeast-induced fever. This research provided informative data that the impaired tryptophan metabolism might be one of the important reasons in elucidating the biochem. basis of the febrile response. In the experiment, the researchers used many compounds, for example, 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methylpyrimidine-2,4(1H,3H)-dione (cas: 2140-69-4Computed Properties of C10H14N2O6).
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-methylpyrimidine-2,4(1H,3H)-dione (cas: 2140-69-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Computed Properties of C10H14N2O6
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem