Balzarini, Jan et al. published their research in Acta Biochimica Polonica in 1987 | CAS: 10356-76-0

4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.HPLC of Formula: 10356-76-0

Differential affinities of pyrimidine nucleoside analogs for deoxythymidine and deoxycytidine kinase determine their incorporation into murine leukemia L1210 cells was written by Balzarini, Jan;De Clercq, Erik. And the article was included in Acta Biochimica Polonica in 1987.HPLC of Formula: 10356-76-0 This article mentions the following:

A number of 5-substituted pyrimidine deoxyribonucleoside (dThd or dCyd) derivatives were evaluated for their effects on the incorporation of dThd and dCyd into the nucleotide pool and nucleic acids of murine leukemia L1210 cells. The dThd kinase and dCyd kinase activity of the cells and the differential affinities of these enzymes for the pyrimidine deoxyribonucleosides may determine the incorporation of dThd and dCyd into the cells. DThd and dCyd were not incorporated into mutant L1210 cells deficient in either dThd kinase or dCyd kinase activity. For a series of 5-substituted dThd and dCyd analogs, a strong correlation was found between their inhibitory effects on the incorporation of dThd or dCyd into cell material and their Ki/Km for dThd kinase and dCyd kinase. Inhibitors of DNA synthesis (i.e., araC) and RNA synthesis (i.e., actinomycin D) suppressed the incorporation of dThd, most likely due to an inhibitory activity at the dThd kinase level (through the allosteric action of dTTP or slow regeneration of dThd kinase). In the experiment, the researchers used many compounds, for example, 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0HPLC of Formula: 10356-76-0).

4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.HPLC of Formula: 10356-76-0

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem