Perylenyltriazoles inhibit reproduction of enveloped viruses was written by Aralov, Andrey V.;Proskurin, Gleb V.;Orlov, Alexey A.;Kozlovskaya, Liubov I.;Chistov, Alexey A.;Kutyakov, Sergey V.;Karganova, Galina G.;Palyulin, Vladimir A.;Osolodkin, Dmitry I.;Korshun, Vladimir A.. And the article was included in European Journal of Medicinal Chemistry in 2017.Computed Properties of C9H11BrN2O6 This article mentions the following:
1-Substituted 4-perylen-2(3)-yl-1,2,3-triazoles, easily accessible by ‘click’ reaction and combining in one mol. a polyaromatic unit and a nitrogen heterocycle, were found to strongly inhibit the reproduction of enveloped viruses. 5-[4-(Perylen-3-yl)-1,2,3-triazol-1-yl]-uridine and 2-[1-(2-hydroxyethyl)-1,2,3-triazol-4-yl]perylene show EC50 of 0.031 and 0.023 μM, resp., against tick-borne encephalitis virus (TBEV). Remarkably, the nucleoside unit appears to be not essential for antiviral activity. These results provide deeper understanding of structural basis of activity for this new class of antivirals. In the experiment, the researchers used many compounds, for example, 5-Bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (cas: 957-75-5Computed Properties of C9H11BrN2O6).
5-Bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (cas: 957-75-5) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Computed Properties of C9H11BrN2O6
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem