Three-Component Coupling of α-Trifluoromethyl Carbonyls, Azides and Amines for the Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles was written by Gao, Ge;Kuantao;Mao;Lv, Leiyang;Li, Zhiping. And the article was included in Advanced Synthesis & Catalysis in 2022.Reference of 582-52-5 This article mentions the following:
A metal-free three-component coupling of α-CF3 carbonyls, azides and amines for the regioselective synthesis of 1,4,5-trisubstituted 1,2,3-triazoles has been established. Various substituted amide-functionalized 1,2,3-triazoles I (Ar = Ph, 3-O2NC6H4, 3-pyridyl, etc.; R = Me, Ph, 4-BrC6H4, 2-naphthyl, 5-methyl-2-furyl, etc.; X = 1-pyrrolidinyl, 1-piperidinyl, etc.) were obtained when the enolizable α-CF3 ketones RC(O)CH2CF3 were reacted with azides ArN3 and amines HX in aqueous reaction medium. Control and 18O-labeling experiments revealed that the in situ generated β-oxo amide was responsible for the formal oxygen-shift and the subsequent [3+2] cycloaddition reaction, with amine as both the catalyst and reactant. In the case of non-enolizable α-CF3 esters F3CCH2CO2R1 (R1 = PhCH2, 1-adamantylmethyl, etc.), the densely functionalized 5-amino 1,2,3-triazoles II were achieved exclusively, which could enable the late-stage functionalization of complex biol. mols. In the experiment, the researchers used many compounds, for example, (3aR,5S,6S,6aR)-5-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (cas: 582-52-5Reference of 582-52-5).
(3aR,5S,6S,6aR)-5-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (cas: 582-52-5) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Reference of 582-52-5
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem