Day: February 3, 2023

Impact of low molecular weight excipient octaacetylmaltose on the liquid crystalline ordering and molecular dynamics in the supercooled liquid and glassy state of itraconazole was written by Kaminska, E.;Tarnacka, M.;Kolodziejczyk, K.;Dulski, M.;Zakowiecki, D.;Hawelek, L.;Adrjanowicz, K.;Zych, M.;Garbacz, G.;Kaminski, K.. And the article was included in European Journal of Pharmaceutics and Biopharmaceutics in 2014.Synthetic Route of C28H38O19 This article mentions the following:

Different exptl. and theor. techniques were applied to investigate basic phys. properties of very stable and homogeneous solid dispersions formed by itraconazole and octaacetylmaltose. Differential scanning calorimetry as well as semi-empirical calculations have indicated that liquid crystalline ordering in itraconazole was completely suppressed in the binary mixtures Mol. dynamics studies with the use of broadband dielec. spectroscopy have shown that the width of the structural relaxation process becomes smaller and fragility drops in solid dispersions with respect to the pure itraconazole. Moreover, the dynamics of secondary relaxation processes was affected by acetylated maltose. As demonstrated, β- and γ-secondary modes shift to higher and lower frequencies, resp. On the other hand, aging experiments revealed that isostructural relaxation times in the glassy state become systematically longer with the addition of modified carbohydrate. This is a very important finding in the context of the current discussion on the factors affecting phys. stability of easily crystallizing APIs. It seems that beside intermol. interactions and local reorientation, the global mobility might control the crystallization of amorphous solid dispersions. Finally, we have demonstrated that itraconazole in binary mixtures dissolves faster and to greater extent with respect to the crystalline and amorphous form of this API. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7Synthetic Route of C28H38O19).

(2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Synthetic Route of C28H38O19

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

B vitamins and prebiotic fructooligosaccharides of cashew apple fermented with probiotic strains Lactobacillus spp., Leuconostoc mesenteroides and Bifidobacterium longum was written by Kaprasob, Ratchadaporn;Kerdchoechuen, Orapin;Laohakunjit, Natta;Somboonpanyakul, Promluck. And the article was included in Process Biochemistry (Oxford, United Kingdom) in 2018.Category: tetrahydrofurans This article mentions the following:

Five strains of probiotic; Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Leuconostoc mesenteroides, and Bifidobacterium longum were targeted for enhancing B-group vitamins and fructo-oligosaccharides (FOS) and raffinose family oligosaccharides (RFO) of cashew apple juice (CAJ) that is an underutilized byproduct from cashew nut processing. Although fermentation by Lb. acidophilus and Lb. casei resulted in increasing B-group vitamins contents (19.25% and 23.11%, resp.) than fermented CAJ with others probiotic, vitamin B2 levels of fermented CAJ were not different significantly. Results also indicated total sugar contents of fructose, glucose, galactose, sucrose, melibiose, and maltotriose were decreased during 48 h of fermentation The CAJ fermented with Lb. acidophilus and Lb. plantarum had higher oligosaccharide contents (RFO and FOS). The CAJ fermented with Lb. acidophilus had the highest FOS of 1-kestose (GF₂), nystose (GF₃) and 1F-β-fructofuranosyl nystose (GF₄), whereas fermented with Lb. plantarum had the highest RFO (raffinose and stachyose). These results suggest that fermented CAJ could serve as a new prebiotic source with B-group vitamins for functional foods and nutraceutical applications for further human health application. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 470-69-9Category: tetrahydrofurans).

(2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 470-69-9) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Untargeted Metabolomics Reveals Metabolic Changes Linked to Bulb Purpling in Garlic (Allium sativum L.) was written by Leite, Victor S. A.;Reis, Marcelo R.;Pinto, Frederico G.. And the article was included in ACS Food Science & Technology in 2021.Name: (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

Garlic (Allium sativum L.) is a vegetable known worldwide, mainly for its characteristic aroma and flavor and for exhibiting several medicinal properties. This culture has significant economic and social relevance in the world agricultural scenario. Most of the garlic production is sold in fresh bulbs, where for some countries the more purple skin bulbs are more valued in the market. However, there is still no consensus about the factors that intensify the purple color of the garlic bulbs. Here, we employed gas chromatog.-mass spectrometry-based untargeted metabolomics to study the metabolome of dark and light purple garlics. Multivariate statistical anal. revealed distinct metabolite signatures between these garlic groups. As metabolic changes play an important factor in changes in the phenotype of cells or an organism, this report presents a fundamental approach for supporting garlic producers in understanding the factors that intensify the purplish color of garlic bulbs, paving the way for safer garlic production with dark purple bulbs. In addition, the medicinal properties of dark purple garlic were greater than that of the light purple garlic, presenting greater abundance in organosulfur compounds Overall, the data suggest that some organic acid and fatty acids such as malonic acid and docosanoic acid are the key differentiating factors between dark and light purple garlics. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 470-69-9Name: (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 470-69-9) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Name: (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem